Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR2 | O15552 | 4/20 | 0.60 |
| ▸ | HSPA5 | P11021 | 6/20 | 0.59 |
| ▸ | HSPA2 | P54652 | 3/20 | 0.59 |
| ▸ | GCK | P35557 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSPA9 | P38646 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.50 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27228868 | 1.00 | FFAR2 (0.60) | FFAR2HSPA5HSPA2GCKLMNA | |
| SCHEMBL9072828 | 0.83 | HSPA5 (0.49) | FFAR2HSPA5LMNAXBP1TSHR | |
| SCHEMBL5875678 | 0.82 | CYP1A2 (0.62) | FFAR2HSPA5HSPA2LMNAXBP1 | |
| Bromide SCHEMBL11317007 | 0.81 | LMNA (0.57) | FFAR2HSPA5HSPA2LMNAXBP1 | |
| SCHEMBL23804604 | 0.80 | LMNA (0.59) | FFAR2HSPA5HSPA2LMNAXBP1 | |
| SCHEMBL7868173 | 0.80 | LMNA (0.56) | FFAR2HSPA5HSPA2LMNAXBP1 | |
| SCHEMBL7876872 | 0.80 | LMNA (0.59) | FFAR2HSPA5HSPA2LMNAXBP1 | |
| SCHEMBL17152395 | 0.80 | MMP9 (0.43) | FFAR2HSPA5HSPA2GCKLMNA | |
| SCHEMBL7868150 | 0.80 | ALDH1A1 (0.51) | FFAR2HSPA5HSPA2LMNAXBP1 | |
| SCHEMBL1107000 | 0.79 | ADORA2A (0.68) | FFAR2HSPA5HSPA2LMNAXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329400-B1 | INHIBITION OR ANTAGONISM OF MATRIX METALLOPROTEASES, AND/OR TUMOR NECROSIS FACTOR-ALPHA; EXTRACELLULAR MATRIX DEGRADATION, INHIBITION OF SHEDDING OF CELL SURFACE PROTEIN ECTODOMAINS AND CD23 PROTEOLYSIS | GLAXO WELLCOME INC. | 2001-12-11 | — | — | US | disclosed |