Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.34 |
| ▸ | CKS1B | P61024 | 1/20 | 0.34 |
| ▸ | SKP1 | P63208 | 1/20 | 0.34 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14481494 | 0.75 | TP53 (0.44) | TP53MAPTALDH1A1HTTNPC1 | |
| SCHEMBL14481493 | 0.75 | TP53 (0.44) | TP53MAPTALDH1A1HTTNPC1 | |
| SCHEMBL9733 | 0.75 | MEN1 (0.37) | MAPTNPC1RAB9AKDM4E | |
| SCHEMBL14481349 | 0.75 | MAPT (0.42) | TP53MAPTALDH1A1HTTNPC1 | |
| Hydrochloric Acid SCHEMBL2113716 | 0.74 | TP53 (0.44) | TP53MAPTALDH1A1HTTNPC1 | |
| Hydrochloric Acid SCHEMBL715476 | 0.74 | TP53 (0.44) | TP53MAPTALDH1A1HTTNPC1 | |
| SCHEMBL716483 | 0.70 | MAPT (0.38) | TP53MAPTALDH1A1HTTNPC1 | |
| SCHEMBL716484 | 0.70 | MAPT (0.38) | TP53MAPTALDH1A1HTTNPC1 | |
| SCHEMBL11850 | 0.69 | MEN1 (0.42) | MAPTALDH1A1KDM4E | |
| SCHEMBL1726583 | 0.69 | SMN1; SMN2 (0.39) | MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499129-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058108-A1 | QUINOLINE AND QUINOXALINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |