Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11850 | 0.79 | MEN1 (0.42) | MEN1MAPTKMT2ALMNAKDM4E | |
| SCHEMBL6680 | 0.79 | POLB (0.42) | MEN1MAPTKMT2ALMNAKDM4E | |
| SCHEMBL11318 | 0.75 | TP53 (0.41) | MAPTKDM4ENPC1RAB9A | |
| SCHEMBL10202753 | 0.71 | MAPT (0.46) | MEN1MAPTKMT2ALMNAKDM4E | |
| SCHEMBL7307 | 0.71 | ALDH1A1 (0.40) | MAPTLMNAKDM4EL3MBTL1CNR2 | |
| SCHEMBL30014701 | 0.69 | KDM4E (0.50) | MEN1MAPTKMT2AKDM4EPOLB | |
| SCHEMBL7306 | 0.68 | CYP3A4 (0.34) | MEN1MAPTKMT2AKDM4EGAA | |
| SCHEMBL1885037 | 0.68 | ALDH1A1 (0.46) | MEN1KMT2AKDM4EGAAL3MBTL1 | |
| SCHEMBL14531754 | 0.67 | CYP4F2 (0.51) | MEN1MAPTKMT2AKDM4EPOLB | |
| SCHEMBL28176179 | 0.67 | KDM4E (0.44) | MEN1MAPTKMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058109-A1 | FUSED BICYCLIC PYRROLE AND IMIDAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |