Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.33 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9733 | 0.79 | MEN1 (0.37) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL11849 | 0.73 | KMT2A (0.39) | MEN1KMT2AMAPTALDH1A1RXFP1 | |
| SCHEMBL11318 | 0.69 | TP53 (0.41) | MAPTALDH1A1KDM4E | |
| SCHEMBL10202753 | 0.66 | MAPT (0.46) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL28176179 | 0.65 | KDM4E (0.44) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL30014701 | 0.64 | KDM4E (0.50) | MEN1KMT2AMAPTKDM4EGAA | |
| SCHEMBL14531754 | 0.62 | CYP4F2 (0.51) | MEN1KMT2AMAPTKDM4EGAA | |
| SCHEMBL27938524 | 0.61 | FAAH (0.59) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL13091277 | 0.60 | SMN1; SMN2 (0.43) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL3279771 | 0.60 | TSHR (0.48) | MEN1KMT2AMAPTALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499126-A1 | FUSED BICYCLIC PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011058113-A1 | FUSED BICYCLIC PYRIDINE AND PYRAZINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |