Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL11050376 | 0.94 | ALDH1A1 (0.45) | ALDH1A1ALOX15HPGDHSD17B10CA2 | |
| Phthalic Acid SCHEMBL29353383 | 0.91 | ALDH1A1 (0.61) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL486891 | 0.91 | ALDH1A1 (0.61) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL121925 | 0.89 | ALDH1A1 (0.64) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL1896603 | 0.87 | ALDH1A1 (0.61) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL27931439 | 0.87 | ALDH1A1 (0.61) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL2027808 | 0.84 | ALDH1A1 (0.54) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL8720508 | 0.84 | ALDH1A1 (0.70) | ALDH1A1ALOX15HPGDHSD17B10CA12 | |
| Phthalic Acid SCHEMBL1929976 | 0.83 | ALDH1A1 (0.61) | ALDH1A1ALOX15HPGDHSD17B10TDP1 | |
| Phthalic Acid SCHEMBL3960987 | 0.83 | ALDH1A1 (0.61) | ALDH1A1ALOX15HPGDHSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4278598-A | AZO DYES | EASTMAN KODAK COMPANY (US) | 1981-07-14 | — | — | US | disclosed |
| US-4199354-A | BALLASTED IMAGE-DYE PROVIDING MATERIALS | EASTMAN KODAK COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| US-4199355-A | BALLASTED CHROMOGENS | EASTMAN KODAK COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
| US-4139379-A | Photographic elements containing ballasted electron-accepting nucleophilic displacement compounds | EASTMAN KODAK COMPANY (US) | 1979-02-13 | — | — | US | disclosed |
| US-4108850-A | Positive-working immobile photographic azo compounds | EASTMAN KODAK COMPANY (US) | 1978-08-22 | — | — | US | disclosed |
| US-3980479-A | Positive-working immobile photographic compounds which cleave by intramolecular nucleophilic displacement in alkali unless oxidized | EASTMAN KODAK COMPANY (US) | 1976-09-14 | — | — | US | disclosed |