Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPD | P32754 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871935 | 0.86 | SMN1; SMN2 (0.48) | POLBHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL14155650 | 0.86 | TSHR (0.44) | POLBHPGDCYP3A4HPDNPC1 | |
| SCHEMBL2460810 | 0.81 | HPD (0.65) | CYP1A2CYP3A4CYP2C19FLT1FLT4 | |
| SCHEMBL9240067 | 0.81 | HPD (0.46) | POLBHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9711504 | 0.79 | SMN1; SMN2 (0.41) | POLBHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9814693 | 0.79 | SMN1; SMN2 (0.44) | POLBHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9738404 | 0.79 | HPD (0.38) | HPGDCYP1A2CYP3A4CYP2C19FLT1 | |
| SCHEMBL9874527 | 0.79 | HPD (0.42) | POLBHPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL12861176 | 0.79 | ALDH1A1 (0.44) | CYP1A2SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL998548 | 0.78 | SMN1; SMN2 (0.43) | POLBHPGDCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8771959-B2 | Methods for the production of plants resistant to HPPD herbicides | SYNGENTA LIMITED (GB) | 2014-07-08 | — | — | US | claimed |
| EP-2287292-B1 | PLANT DERIVED HYDROXY PHENYL PYRUVATE DIOXYGNEASES (HPPD) RESISTANT AGAINST TRIKETONE HERBICIDES AND TRANSGENIC PLANTS CONTAINING THESE DIOXYGENASES | SYNGENTA LTD (GB) | 2015-04-08 | — | — | EP | disclosed |
| US-8771959-B2 | Methods for the production of plants resistant to HPPD herbicides | SYNGENTA LIMITED (GB) | 2014-07-08 | — | — | US | disclosed |
| US-8771959-B2 | Methods for the production of plants resistant to HPPD herbicides | SYNGENTA LIMITED (GB) | 2014-07-08 | — | — | US | disclosed |
| US-8735660-B2 | Methods for the production of plants resistant to HPPD herbicides | SYNGENTA LIMITED (GB) | 2014-05-27 | — | — | US | disclosed |
| EP-1341903-B1 | PLANT DERIVED HYDROXY PHENYL PYRUVATE DIOXYGNEASES (HPPD) RESISTANT AGAINST TRIKETONE HERBICIDES AND TRANSGENIC PLANTS CONTAINING THESE DIOXYGENASES | SYNGENTA LTD (GB) | 2012-12-26 | — | — | EP | disclosed |
| US-8053641-B2 | Using arabidopsis hydroxy phenyl pyruvate (or pyruvic acid) dioxygenase (HPPD) mutant as screening tool in identifying herbicide resistant plants | SYNGENTA LIMITED (GB) | 2011-11-08 | — | — | US | disclosed |
| US-8053641-B2 | Using arabidopsis hydroxy phenyl pyruvate (or pyruvic acid) dioxygenase (HPPD) mutant as screening tool in identifying herbicide resistant plants | SYNGENTA LIMITED (GB) | 2011-11-08 | — | — | US | disclosed |
| EP-2287292-A2 | Plant derived hydroxy phenyl pyruvate dioxygneases (HPPD) resistant against triketone herbicides and transgenic plants containing these dioxygenases | Syngenta Limited (GB) | 2011-02-23 | — | — | EP | disclosed |
| US-20090172831-A1 | Methods for the production of plants resistant to HPPD herbicides | SYNGENTA LIMITED | 2009-07-02 | — | — | US | disclosed |
| US-5006162-A | Controlling weeds | ICI AMERICAS INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-5006158-A | Herbicides | ICI AMERICAS INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4946981-A | HERBICIDES | ICI AMERICAS INC. (US) | 1990-08-07 | — | — | US | disclosed |
| US-4853028-A | Certain 2-(2-substituted benzoyl)-1,3-cyclohexanediones | STAUFFER CHEMICAL COMPANY (US) | 1989-08-01 | — | — | US | disclosed |
| US-4822906-A | HERBICIDE INTERMEDIATE | STAUFFER CHEMICAL COMPANY (US) | 1989-04-18 | — | — | US | disclosed |
| US-4816066-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| US-4806146-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1989-02-21 | — | — | US | disclosed |
| US-4797150-A | HERBICIDES | STAUFFER CHEMICAL COMPANY (US) | 1989-01-10 | — | — | US | disclosed |
| US-4780127-A | Certain 2-(substituted benzoyl)-1,3-cyclohexanediones and their use as herbicides | STAUFFER CHEMICAL COMPANY (US) | 1988-10-25 | — | — | US | disclosed |
| US-4695673-A | Process for the production of acylated 1,3-dicarbonyl compounds | STAUFFER CHEMICAL COMPANY (US) | 1987-09-22 | — | — | US | disclosed |