SCHEMBL1132020

SCHEMBL1132020

CCOC(=O)C(C)=Cc1cc(-c2ccc(O)cc2)n(C2CCCCC2)n1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 2/20 0.42
FABP3 P05413 3/20 0.38
FABP4 P15090 3/20 0.38
FAAH O00519 6/20 0.37
PDE7A Q13946 2/20 0.35
KCNJ6 P48051 1/20 0.35
KCNJ5 P48544 1/20 0.35
KCNJ3 P48549 1/20 0.35
KCNH2 Q12809 2/20 0.35
ESR1 P03372 1/20 0.34
ALDH1A1 P00352 1/20 0.34
MAPK1 P28482 1/20 0.34
CMKLR1 Q99788 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1132017 1.00 PTGS2 (0.42) PTGS2FABP3FABP4FAAHPDE7A
SCHEMBL1131830 0.86 PTPN1 (0.46) FABP3FABP4ALDH1A1CMKLR1
SCHEMBL1131834 0.86 PTPN1 (0.46) FABP3FABP4ALDH1A1CMKLR1
SCHEMBL1131611 0.85 PTGS2 (0.43) PTGS2FABP3FABP4PDE7AKCNJ6
SCHEMBL5861842 0.85 PTGS2 (0.43) PTGS2FABP3FABP4PDE7AKCNJ6
SCHEMBL1131371 0.81 FAAH (0.37) PTGS2FABP3FABP4FAAHKCNJ6
SCHEMBL1131367 0.81 FAAH (0.37) PTGS2FABP3FABP4FAAHKCNJ6
SCHEMBL1132056 0.78 FAAH (0.37) FABP3FABP4FAAHCMKLR1
SCHEMBL1132015 0.77 MEN1 (0.37) FAAHALDH1A1MAPK1
SCHEMBL1132013 0.77 MEN1 (0.37) FAAHALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1663105-B1 CYCLOALKYL HETEROCYCLES FOR TREATING HEPATITIS C VIRUS BRISTOL MYERS SQUIBB CO (US) 2011-02-16 EP disclosed