Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.34 |
| ▸ | SI | P14410 | 1/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946068 | 0.81 | MAPT (0.40) | JAK2MEN1KMT2ACDK4CDK2 | |
| SCHEMBL14850865 | 0.77 | NISCH (0.40) | JAK2CDK4CDK2GPR52FLT3 | |
| SCHEMBL14850867 | 0.77 | GPR52 (0.37) | JAK2MEN1KMT2ACDK4CDK2 | |
| SCHEMBL7946636 | 0.76 | ALDH1A1 (0.44) | MEN1KMT2ACDK4CDK2GAA | |
| SCHEMBL7945899 | 0.76 | APP (0.40) | MEN1KMT2AFLT3MKNK1MKNK2 | |
| SCHEMBL11160835 | 0.75 | KMT2A (0.42) | JAK2TDP1MEN1KMT2ACDK4 | |
| SCHEMBL2632547 | 0.75 | ALDH1A1 (0.51) | MEN1KMT2AGAASMN1; SMN2TP53 | |
| SCHEMBL8043074 | 0.74 | KMT2A (0.45) | MEN1KMT2ACDK4CDK2GPR52 | |
| SCHEMBL2632548 | 0.74 | CA12 (0.42) | MEN1KMT2ACDK4CDK2GPR52 | |
| SCHEMBL11000112 | 0.72 | CDK2 (0.40) | JAK2TDP1MEN1KMT2ACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297365-A | Benzimidazoles and pharmaceutical preparations containing such compounds | CIBA-GEIGY CORPORATION (US) | 1981-10-27 | — | — | US | disclosed |