Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11330108 | 0.86 | TSHR (0.56) | TSHRMEN1KMT2ATP53LMNA | |
| SCHEMBL11328174 | 0.84 | CYP3A4 (0.43) | TSHRMEN1KMT2ATP53CNR2 | |
| SCHEMBL11300194 | 0.83 | TSHR (0.55) | TSHRMEN1KMT2ATP53LMNA | |
| SCHEMBL11323696 | 0.81 | CTSD (0.48) | MAPK1TP53PSEN1PSEN2APH1B | |
| SCHEMBL11320422 | 0.80 | SMN1; SMN2 (0.43) | KMT2AALDH1A1 | |
| SCHEMBL11328429 | 0.79 | PPARG (0.43) | TSHRTP53THRBLMNAALDH1A1 | |
| SCHEMBL11325178 | 0.79 | TSHR (0.58) | TSHRMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL11315622 | 0.78 | MEN1 (0.53) | TSHRMEN1KMT2ATP53THRB | |
| SCHEMBL11298142 | 0.77 | SMN1; SMN2 (0.43) | KMT2ACNR2ALDH1A1 | |
| SCHEMBL11832281 | 0.77 | KMT2A (0.60) | TSHRMEN1KMT2AMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243678-A | GASTROINTESTINAL DISORDERS, LIVER DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-01-06 | — | — | US | disclosed |