Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11330151 | 0.90 | MCHR1 (0.47) | TSHRKMT2APTGDR2MMEMMEL1 | |
| SCHEMBL11330108 | 0.87 | TSHR (0.56) | TSHRMEN1KMT2APTGDR2MME | |
| SCHEMBL11300194 | 0.84 | TSHR (0.55) | TSHRMEN1KMT2APTGDR2MME | |
| SCHEMBL11324670 | 0.82 | TSHR (0.56) | TSHRMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL11320533 | 0.79 | TSHR (0.54) | TSHRMEN1KMT2AALDH1A1ATM | |
| SCHEMBL11328985 | 0.77 | MEN1 (0.57) | TSHRMEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL11436747 | 0.76 | KCNH2 (0.50) | TSHRGAAMAPTLMNAMCHR1 | |
| SCHEMBL11319126 | 0.76 | TSHR (0.53) | TSHRMEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL11315622 | 0.75 | MEN1 (0.53) | TSHRMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL11332478 | 0.74 | LPAR1 (0.44) | TSHRMMEMMEL1SLC6A9LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243678-A | GASTROINTESTINAL DISORDERS, LIVER DISORDERS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-01-06 | — | — | US | disclosed |