Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.72 |
| ▸ | KDR | P35968 | 10/20 | 0.72 |
| ▸ | AXL | P30530 | 6/20 | 0.72 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.72 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.72 |
| ▸ | MERTK | Q12866 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | HCK | P08631 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | ABL2 | P42684 | 1/20 | 0.52 |
| ▸ | FRK | P42685 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1132200 | 1.00 | MET (0.72) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132137 | 0.95 | MET (0.69) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132133 | 0.95 | MET (0.69) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132315 | 0.95 | MET (0.80) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132306 | 0.95 | MET (0.80) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132542 | 0.93 | MET (0.70) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132546 | 0.93 | MET (0.70) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132115 | 0.92 | MET (0.83) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132150 | 0.91 | MET (0.68) | METKDRAXLPDGFRAPDGFRB | |
| SCHEMBL1132157 | 0.91 | MET (0.68) | METKDRAXLPDGFRAPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140378409-A1 | EFFECT POTENTIATOR FOR ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-12-25 | — | — | US | claimed |
| EP-2799070-A1 | EFFECT POTENTIATOR FOR ANTITUMOR AGENTS | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-11-05 | — | — | EP | claimed |
| EP-2287155-B1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2013-07-17 | — | — | EP | claimed |
| US-8304427-B2 | Acylthiourea compound or salt thereof, and use thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-11-06 | — | — | US | claimed |
| EP-2287155-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE OF THE COMPOUND OR THE SALT | Taiho Pharmaceutical Co., Ltd. (JP) | 2011-02-23 | — | — | EP | claimed |
| US-20110034439-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2011-02-10 | — | — | US | claimed |
| CN-112870195-A | Therapeutic agent for osteoporosis | 国立大学法人东京农工大学 | 2021-06-01 | — | — | CN | disclosed |
| EP-3053581-A1 | THERAPEUTIC AGENT FOR OSTEOPOROSIS | National University Corporation Tokyo University Of Agriculture and Technology (JP) | 2016-08-10 | — | — | EP | disclosed |
| US-9149471-B2 | Therapeutic agent for osteoporosis | NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY (JP) | 2015-10-06 | — | — | US | disclosed |
| US-20150164879-A1 | THERAPEUTIC AGENT FOR OSTEOPOROSIS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-06-18 | — | — | US | disclosed |
| US-20140378409-A1 | EFFECT POTENTIATOR FOR ANTITUMOR AGENTS | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2014-12-25 | — | — | US | disclosed |
| EP-2799070-A1 | EFFECT POTENTIATOR FOR ANTITUMOR AGENTS | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-11-05 | — | — | EP | disclosed |
| EP-2287155-B1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2013-07-17 | — | — | EP | disclosed |
| US-8304427-B2 | Acylthiourea compound or salt thereof, and use thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2012-11-06 | — | — | US | disclosed |
| EP-2287155-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE OF THE COMPOUND OR THE SALT | Taiho Pharmaceutical Co., Ltd. (JP) | 2011-02-23 | — | — | EP | disclosed |
| US-20110034439-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034439-A1 | ACYLTHIOUREA COMPOUND OR SALT THEREOF, AND USE THEREOF | MET, HGF, STAT6 | MET 1/4885KDR 296/4885AXL 568/4885 |
| US-20140378409-A1 | EFFECT POTENTIATOR FOR ANTITUMOR AGENTS | MCL1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS | MET 579/4885KDR 3629/4885AXL 4213/4885 |
| US-20150164879-A1 | THERAPEUTIC AGENT FOR OSTEOPOROSIS | PTH1R, CALCR, SOST | MET 1748/4885KDR 4711/4885AXL 3249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.