Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11055205 | 0.86 | F2 (0.39) | MAP2K2MAP2K1PKMPOLBGAA | |
| SCHEMBL11051492 | 0.84 | POLB (0.44) | POLBMEN1KMT2ACA1CA2 | |
| SCHEMBL11316936 | 0.83 | KMT2A (0.42) | MEN1KMT2ACA1CA2NPC1 | |
| SCHEMBL11315297 | 0.83 | CYP1A2 (0.43) | POLBATMCA1CA2NPC1 | |
| SCHEMBL11318482 | 0.81 | MAP2K2 (0.44) | MAP2K2MAP2K1PKMPOLBGAA | |
| SCHEMBL11407156 | 0.81 | F2 (0.36) | MAP2K2MAP2K1PKMPOLBGAA | |
| SCHEMBL11320624 | 0.81 | RAB9A (0.56) | PKMPOLBGAACA1CA2 | |
| SCHEMBL11423498 | 0.81 | PKM (0.51) | MAP2K2MAP2K1PKMPOLBCTDSP1 | |
| SCHEMBL11431322 | 0.80 | PKM (0.50) | MAP2K2MAP2K1PKMPOLBCTDSP1 | |
| SCHEMBL11285564 | 0.79 | PKM (0.53) | PKMMEN1KMT2AATMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4283555-A | Amidinoureas | WILLIAM H. RORER, INC. (US) | 1981-08-11 | — | — | US | disclosed |
| US-4219567-A | ANTIULCER AGENTS | WILLIAM H. RORER, INC. (US) | 1980-08-26 | — | — | US | disclosed |
| US-4183956-A | Method for treating gastrointestinal spasms, gastrointestinal hyperacidity and hypertensive disorders with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-01-15 | — | — | US | disclosed |