SCHEMBL11323613

SCHEMBL11323613

Cc1cc([N+](=O)[O-])c(Cl)c([N+](=O)[O-])c1S(=O)(=O)O.[KH]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 4/20 0.44
NSD2 O96028 1/20 0.39
GAA P10253 1/20 0.39
PLCG1 P19174 1/20 0.39
DNMT1 P26358 1/20 0.39
CASP6 P55212 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ALDH1A1 P00352 4/20 0.38
TSHR P16473 3/20 0.37
HPGD P15428 2/20 0.36
TDP1 Q9NUW8 2/20 0.36
CYP1A2 P05177 2/20 0.36
VCAM1 P19320 2/20 0.36
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.36
HIF1A Q16665 1/20 0.36
TXNRD1 Q16881 1/20 0.36
TXNRD3 Q86VQ6 1/20 0.36
TXNRD2 Q9NNW7 1/20 0.36
GRIN2D O15399 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11333385 0.84 VCAM1 (0.39) GPR35ALDH1A1TSHRHPGDTDP1
SCHEMBL195920 0.84 NSD2 (0.46) GPR35NSD2GAAPLCG1DNMT1
SCHEMBL11321822 0.83 VCAM1 (0.44) GPR35ALDH1A1TSHRHPGDTDP1
Potassium Ion SCHEMBL11323603 0.83 TSHR (0.38) GPR35ALDH1A1TSHRHPGDTDP1
SCHEMBL6690333 0.77 GPR35 (0.55) GPR35NSD2GAAPLCG1DNMT1
SCHEMBL11435748 0.77 TSHR (0.52) GPR35ALDH1A1TSHRHPGDTDP1
SCHEMBL30350503 0.77 TSHR (0.52) GPR35ALDH1A1TSHRHPGDTDP1
SCHEMBL8649537 0.75 CYP1A2 (0.52) GPR35ALDH1A1TSHRHPGDTDP1
SCHEMBL11802146 0.74 TSHR (0.49) GPR35NSD2GAAPLCG1DNMT1
SCHEMBL4479896 0.73 NSD2 (0.53) GPR35NSD2GAAPLCG1DNMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4297127-A PREEMERGENCE HERBICIDES AMERICAN CYANAMID COMPANY (US) 1981-10-27 US disclosed
US-4251264-A 4-CYANO SUBSTITUTED AMERICAN CYANAMID COMPANY (US) 1981-02-17 US disclosed
US-4166908-A SELECTIVE PREEMERGENT ACTIVITY AMERICAN CYANAMID COMPANY (US) 1979-09-04 US disclosed
US-4165231-A 2,6-Dinitroaniline herbicides AMERICAN CYANAMID COMPANY (US) 1979-08-21 US disclosed
US-4025538-A 2,6-Dinitroaniline herbicides AMERICAN CYANAMID COMPANY (US) 1977-05-24 US disclosed