SCHEMBL11323967

SCHEMBL11323967

O=[N+]([O-])c1cc([N+](=O)[O-])c(CCl)c([N+](=O)[O-])c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 5/20 0.50
ALDH1A1 P00352 9/20 0.48
KMT2A Q03164 5/20 0.48
MEN1 O00255 4/20 0.48
TDP1 Q9NUW8 4/20 0.48
MAPK1 P28482 4/20 0.48
MAPT P10636 3/20 0.48
HPGD P15428 2/20 0.48
HIF1A Q16665 2/20 0.48
KDM4E B2RXH2 1/20 0.48
TTR P02766 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48
ALOX15 P16050 1/20 0.48
ALOX12 P18054 1/20 0.48
RECQL P46063 1/20 0.48
PMP22 Q01453 1/20 0.48
HSD17B10 Q99714 1/20 0.48
HTT P42858 3/20 0.47
CYP3A4 P08684 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8213405 0.83 TSHR (0.46) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL9318057 0.82 ALDH1A1 (0.59) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL11774795 0.82 ALDH1A1 (0.52) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL7497845 0.78 ALDH1A1 (0.48) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL10919990 0.78 ALDH1A1 (0.61) GPR35ALDH1A1KMT2ATDP1HSD17B10
SCHEMBL8744302 0.78 ALDH1A1 (0.53) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL28252618 0.78 ALDH1A1 (0.52) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL4000997 0.78 HTT (0.53) GPR35ALDH1A1KMT2AMEN1TDP1
Trinitrophenol SCHEMBL14675401 0.77 GPR35 (0.69) GPR35ALDH1A1KMT2AMEN1TDP1
SCHEMBL27479646 0.77 ALDH1A1 (0.47) GPR35ALDH1A1KMT2AMEN1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4307258-A 2,2*,4,4*,6,6*-HEXANITROSTILBENE PREPARED BY REACTION WITH HYDROXIDE ION SUPPLIED BY AQUEOUS AMINES AND AMMONIA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1981-12-22 US claimed
US-4199532-A Method for the production of hexanitrostilbene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1980-04-22 US claimed
US-4307258-A 2,2*,4,4*,6,6*-HEXANITROSTILBENE PREPARED BY REACTION WITH HYDROXIDE ION SUPPLIED BY AQUEOUS AMINES AND AMMONIA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1981-12-22 US disclosed
US-4307258-A 2,2*,4,4*,6,6*-HEXANITROSTILBENE PREPARED BY REACTION WITH HYDROXIDE ION SUPPLIED BY AQUEOUS AMINES AND AMMONIA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1981-12-22 US disclosed
US-4307258-A 2,2*,4,4*,6,6*-HEXANITROSTILBENE PREPARED BY REACTION WITH HYDROXIDE ION SUPPLIED BY AQUEOUS AMINES AND AMMONIA THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1981-12-22 US disclosed
US-4199532-A Method for the production of hexanitrostilbene THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1980-04-22 US disclosed