SCHEMBL11326422

SCHEMBL11326422

CNC(=O)NCCSCc1ocnc1C

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.39
MAPT P10636 5/20 0.37
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
HTT P42858 1/20 0.37
ALDH1A1 P00352 9/20 0.35
LMNA P02545 4/20 0.35
SMN1; SMN2 Q16637 4/20 0.34
MAPK1 P28482 1/20 0.34
HPGD P15428 3/20 0.33
USP2 O75604 2/20 0.33
NPC1 O15118 1/20 0.33
RECQL P46063 1/20 0.33
RAB9A P51151 1/20 0.33
POLB P06746 2/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
FBP1 P09467 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11643707 0.80 ALDH1A1 (0.35) ACHEMAPTKMT2AMEN1ALDH1A1
SCHEMBL11315005 0.80 SMN1; SMN2 (0.33) MAPTHTTALDH1A1LMNASMN1; SMN2
SCHEMBL11237497 0.79 ACHE (0.53) ACHEMAPTKMT2AMEN1ALDH1A1
SCHEMBL11237518 0.79 ACHE (0.53) ACHEMAPTKMT2AMEN1ALDH1A1
SCHEMBL11322306 0.77 LMNA (0.40) MAPTKMT2AMEN1HTTALDH1A1
SCHEMBL11089815 0.77 SMN1; SMN2 (0.36) MAPTKMT2AMEN1HTTALDH1A1
SCHEMBL11322303 0.75 ALDH1A1 (0.32) MAPTALDH1A1SMN1; SMN2MAPK1
SCHEMBL11315117 0.74 LMNA (0.36) ACHEMAPTKMT2AHTTALDH1A1
SCHEMBL11326745 0.74 SMN1; SMN2 (0.50) ACHEKMT2AMEN1ALDH1A1LMNA
SCHEMBL11181962 0.73 LMNA (0.38) ACHEMAPTKMT2AMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4307101-A ANTIHISTAMINES AND ANTISECRETORY AGENTS OF THE THIOUREA OR UREA DERIVATIVES 5,6,7,8-TETRAHYDROIMIDAZO(1,5A)PYRIDINE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-12-22 US disclosed
US-4293697-A ANTIHISTAMINES SMITH, KLINE & FRENCH LABORATORIES LIMITED (GB) 1981-10-06 US disclosed
US-4230865-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-10-28 US disclosed
US-4226874-A ANTIHISTAMINES, ANTISECRETORY AGENTS, GASTRIC JUICE SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1980-10-07 US disclosed
US-4151288-A ANTHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-04-24 US disclosed
US-4137234-A ANTIHISTAMINES SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) 1979-01-30 US disclosed
US-4018931-A INHIBITION OF H-2 HISTAMINE RECEPTORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1977-04-19 US disclosed
US-3950353-A HISTAMINE INHIBITORS SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) 1976-04-13 US disclosed