Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11787894 | 0.89 | CHRNA7 (0.52) | CHRNA7DRD2HTR1AKCNH2NR1I2 | |
| SCHEMBL11338350 | 0.87 | CHRNA7 (0.50) | CHRNA7DRD2HTR1AKCNH2NR1I2 | |
| SCHEMBL11784439 | 0.86 | CHRNA7 (0.56) | CHRNA7DRD2KCNH2HTR2AHTR2C | |
| SCHEMBL11244654 | 0.83 | SIGMAR1 (0.54) | CHRNA7SIGMAR1 | |
| SCHEMBL11335321 | 0.82 | HTR1A (0.68) | DRD2HTR1AKCNH2NR1I2ADRB1 | |
| SCHEMBL11783437 | 0.82 | DRD2 (0.70) | CHRNA7DRD2HTR1AKCNH2NR1I2 | |
| Hydrochloric Acid SCHEMBL11335313 | 0.81 | DRD2 (0.69) | CHRNA7DRD2HTR1AKCNH2NR1I2 | |
| SCHEMBL11230661 | 0.81 | SIGMAR1 (0.52) | ADRA2AADRA2BADRA2CHTR2BHTR7 | |
| SCHEMBL11339432 | 0.80 | TLR9 (0.44) | DRD2KDM4ETLR9 | |
| SCHEMBL11228025 | 0.80 | SIGMAR1 (0.59) | CHRNA7SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4302589-A | ANTIPSYCHOTIC | AMERICAN CYANAMID COMPANY (US) | 1981-11-24 | — | — | US | disclosed |