SCHEMBL11328343

SCHEMBL11328343

CCCCN(CCCC)c1c([N+](=O)[O-])cc(C)c(C)c1[N+](=O)[O-]

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.51
CYP3A4 P08684 2/20 0.51
MAPK1 P28482 2/20 0.51
TDP1 Q9NUW8 3/20 0.46
TSHR P16473 2/20 0.46
CYP1A2 P05177 1/20 0.41
VCAM1 P19320 2/20 0.39
ALDH1A1 P00352 2/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
GRIN2D O15399 1/20 0.35
GRIN3B O60391 1/20 0.35
GRIN1 Q05586 1/20 0.35
GRIN2A Q12879 1/20 0.35
GRIN2B Q13224 1/20 0.35
GRIN2C Q14957 1/20 0.35
GRIN3A Q8TCU5 1/20 0.35
ALDH3A1 P30838 1/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
HCAR3 P49019 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11524765 0.94 MAPT (0.59) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL11317064 0.91 TDP1 (0.55) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL8331984 0.86 CYP3A4 (0.49) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL11335649 0.85 CYP1A2 (0.45) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL11522696 0.84 CYP1A2 (0.41) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL11524922 0.84 MAPT (0.41) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL7529889 0.82 CYP3A4 (0.40) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL11320225 0.81 TDP1 (0.43) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL8371130 0.80 VCAM1 (0.39) MAPTCYP3A4MAPK1TDP1TSHR
SCHEMBL11334330 0.78 CYP1A2 (0.44) MAPTCYP3A4MAPK1TDP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4297127-A PREEMERGENCE HERBICIDES AMERICAN CYANAMID COMPANY (US) 1981-10-27 US disclosed
US-4251264-A 4-CYANO SUBSTITUTED AMERICAN CYANAMID COMPANY (US) 1981-02-17 US disclosed
US-4166908-A SELECTIVE PREEMERGENT ACTIVITY AMERICAN CYANAMID COMPANY (US) 1979-09-04 US disclosed
US-4165231-A 2,6-Dinitroaniline herbicides AMERICAN CYANAMID COMPANY (US) 1979-08-21 US disclosed
US-4136117-A PREPARATION OF 2,6-DINITROANILINES AMERICAN CYANAMID COMPANY (US) 1979-01-23 US disclosed
US-4124639-A N-alkoxyalkyl-2,6-dinitroaniline herbicides AMERICA CYANAMID COMPANY (US) 1978-11-07 US disclosed
US-4101582-A 2,6-Dinitroaniline herbicides AMERICAN CYANAMID COMPANY (US) 1978-07-18 US disclosed
US-4025538-A 2,6-Dinitroaniline herbicides AMERICAN CYANAMID COMPANY (US) 1977-05-24 US disclosed