Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.90 |
| ▸ | BCHE | P06276 | 4/20 | 0.90 |
| ▸ | MEN1 | O00255 | 4/20 | 0.90 |
| ▸ | BLM | P54132 | 4/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.90 |
| ▸ | MAPT | P10636 | 3/20 | 0.90 |
| ▸ | THRB | P10828 | 3/20 | 0.90 |
| ▸ | HPGD | P15428 | 3/20 | 0.90 |
| ▸ | CASP1 | P29466 | 3/20 | 0.90 |
| ▸ | RECQL | P46063 | 3/20 | 0.90 |
| ▸ | CASP7 | P55210 | 3/20 | 0.90 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.90 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.90 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.90 |
| ▸ | TERT | O14746 | 3/20 | 0.60 |
| ▸ | MITF | O75030 | 2/20 | 0.60 |
| ▸ | NSD2 | O96028 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629831 | 0.99 | ACHE (0.92) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL16912939 | 0.99 | ACHE (0.92) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL30379131 | 0.95 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL55279 | 0.95 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| Hydrochloric Acid SCHEMBL5482694 | 0.94 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| Iodide SCHEMBL14996 | 0.94 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL16331307 | 0.94 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| Bromide SCHEMBL30669741 | 0.94 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| Iodide SCHEMBL29351886 | 0.94 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| Iodide SCHEMBL29527724 | 0.94 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964790-B1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES LTD (US) | 2023-06-07 | — | — | EP | claimed |
| US-20180100851-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES LTD (US) | 2018-04-12 | — | — | US | claimed |
| US-20170003276-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES LTD (US) | 2017-01-05 | — | — | US | claimed |
| US-9470694-B2 | Simplified nuclei analysis platform and biomarker matrix that supports genotoxic mode of action determinations | LITRON LABORATORIES LTD. (US) | 2016-10-18 | — | — | US | claimed |
| EP-2964790-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | Litron Laboratories, Ltd (US) | 2016-01-13 | — | — | EP | claimed |
| WO-2014164312-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES, LTD (US) | 2014-10-09 | — | — | WO | claimed |
| US-20140255948-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES, LTD. (US) | 2014-09-11 | — | — | US | claimed |
| US-20140017673-A1 | METHOD FOR ENUMERATING EUKARYOTIC CELL MICRONUCLEI WITH AN EMPHASIS ON SIMULTANEOUSLY ACQUIRING CYTOTOXICITY AND MODE OF ACTION INFORMATION | LITRON LABORATORIES, LTD. (US) | 2014-01-16 | — | — | US | claimed |
| US-11828763-B2 | Simplified nuclei analysis platform and biomarker matrix that supports genotoxic mode of action determinations | LITRON LABORATORIES, LTD. (US) | 2023-11-28 | — | — | US | disclosed |
| EP-2964790-B1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES LTD (US) | 2023-06-07 | — | — | EP | disclosed |
| US-11016101-B2 | Simplified nuclei analysis platform and biomarker matrix that supports genotoxic mode of action determinations | LITRON LABORATORIES LTD. (US) | 2021-05-25 | — | — | US | disclosed |
| US-20210132081-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES LTD (US) | 2021-05-06 | — | — | US | disclosed |
| CN-112566649-A | Microbiota Restoration Therapy (MRT) compositions and methods of manufacture | 雷柏奥提斯有限公司 | 2021-03-26 | — | — | CN | disclosed |
| US-10802013-B2 | Simplified nuclei analysis platform and biomarker matrix that supports genotoxic mode of action determinations | LITRON LABORATORIES LTD. (US) | 2020-10-13 | — | — | US | disclosed |
| WO-2014164312-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES, LTD (US) | 2014-10-09 | — | — | WO | disclosed |
| US-20140255948-A1 | SIMPLIFIED NUCLEI ANALYSIS PLATFORM AND BIOMARKER MATRIX THAT SUPPORTS GENOTOXIC MODE OF ACTION DETERMINATIONS | LITRON LABORATORIES, LTD. (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140017673-A1 | METHOD FOR ENUMERATING EUKARYOTIC CELL MICRONUCLEI WITH AN EMPHASIS ON SIMULTANEOUSLY ACQUIRING CYTOTOXICITY AND MODE OF ACTION INFORMATION | LITRON LABORATORIES, LTD. (US) | 2014-01-16 | — | — | US | disclosed |
| US-20120190028-A1 | NUCLEIC ACIDS AND METHODS FOR THE DETECTION OF ENTEROBACTER SAKAZAKII (CRONOBACTER SPP.) | BIOTECON DIAGNOSTICS GMBH (DE) | 2012-07-26 | — | — | US | disclosed |
| EP-2287333-A1 | Nucleic acids and methods for the detection of enterobacter sakazakii (cronobacter spp.) | Biotecon Diagnostics GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |
| WO-2011015356-A1 | NUCLEIC ACIDS AND METHODS FOR THE DETECTION OF ENTEROBACTER SAKAZAKII (CRONOBACTER SPP.) | BIOTECON DIAGNOSTICS GMBH (DE) | 2011-02-10 | — | — | WO | disclosed |