Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 7/20 | 0.98 |
| ▸ | BCHE | P06276 | 4/20 | 0.98 |
| ▸ | MEN1 | O00255 | 4/20 | 0.98 |
| ▸ | BLM | P54132 | 4/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.98 |
| ▸ | THRB | P10828 | 3/20 | 0.98 |
| ▸ | HPGD | P15428 | 3/20 | 0.98 |
| ▸ | CASP1 | P29466 | 3/20 | 0.98 |
| ▸ | RECQL | P46063 | 3/20 | 0.98 |
| ▸ | CASP7 | P55210 | 3/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
| ▸ | TERT | O14746 | 3/20 | 0.67 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.67 |
| ▸ | MITF | O75030 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL290404 | 1.00 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL55279 | 0.99 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL30379131 | 0.99 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| Iodide SCHEMBL14996 | 0.98 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| Hydrochloric Acid SCHEMBL5482694 | 0.98 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL16331307 | 0.98 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| Iodide SCHEMBL29527724 | 0.98 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| Iodide SCHEMBL29351886 | 0.98 | ACHE (1.00) | ACHEBCHEMEN1BLMKMT2A | |
| Water SCHEMBL9106337 | 0.97 | ACHE (0.98) | ACHEBCHEMEN1BLMKMT2A | |
| SCHEMBL3629831 | 0.95 | ACHE (0.92) | ACHEBCHEMEN1BLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230338340-A1 | Methods of Treating Cystic Fibrosis | DARTMOUTH COLLEGE (US) | 2023-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230338340-A1 | Methods of Treating Cystic Fibrosis | CFTR, DAB2IP, CTTN | ACHE 3517/4885BCHE 2218/4885MEN1 4782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.