Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1358311 | 0.82 | KDM4E (0.67) | POLBLMNAUSP2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL1358374 | 0.81 | KDM4E (0.65) | POLBLMNAUSP2NPC1RAB9A | |
| SCHEMBL1357994 | 0.81 | ALDH1A1 (0.55) | MEN1KMT2ALMNAMAPTHTT | |
| Bromide SCHEMBL11346725 | 0.80 | ALDH1A1 (0.54) | MEN1KMT2ALMNAMAPTHTT | |
| Hydrochloric Acid SCHEMBL11317293 | 0.80 | ALDH1A1 (0.54) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL27780252 | 0.80 | CCNE1 (0.53) | MEN1KMT2APOLBLMNAMAPT | |
| SCHEMBL1358966 | 0.78 | CYP1A2 (0.61) | MEN1KMT2APOLBLMNAMAPT | |
| SCHEMBL11478978 | 0.78 | RAB9A (0.53) | MEN1KMT2APOLBLMNAMAPT | |
| SCHEMBL11311373 | 0.77 | NPC1 (0.61) | MEN1KMT2APOLBLMNAMAPT | |
| SCHEMBL11328569 | 0.77 | SCN3A (0.53) | MEN1KMT2APOLBLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4217355-A | N-(I-THIAZOLYL)-A-(SUBSTITUTED AMINO)AMIDES, ANTIINFLAMMATORY, IMMUNOREGULATIVE | PFIZER INC. (US) | 1980-08-12 | — | — | US | claimed |
| US-4305949-A | ANTIINFLAMMATORY AGENTS AND IMMUNOREGULATORY AGENTS | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4305949-A | ANTIINFLAMMATORY AGENTS AND IMMUNOREGULATORY AGENTS | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
| EP-0005070-B1 | N-(2-THIAZOLYL)AMIDES AND THEIR USE AS ANTI-INFLAMMATORY AND IMMUNOREGULATORY AGENTS | PFIZER INC. (US) | 1981-12-09 | — | — | EP | disclosed |
| US-4217355-A | N-(I-THIAZOLYL)-A-(SUBSTITUTED AMINO)AMIDES, ANTIINFLAMMATORY, IMMUNOREGULATIVE | PFIZER INC. (US) | 1980-08-12 | — | — | US | disclosed |
| US-4217355-A | N-(I-THIAZOLYL)-A-(SUBSTITUTED AMINO)AMIDES, ANTIINFLAMMATORY, IMMUNOREGULATIVE | PFIZER INC. (US) | 1980-08-12 | — | — | US | disclosed |
| EP-0005070-A2 | N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents | PFIZER INC. (US) | 1979-10-31 | — | — | EP | disclosed |