Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.51 |
| ▸ | CLK1 | P49759 | 3/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 4/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11340563 | 0.82 | LIMK1 (0.47) | LIMK1CLK1CDC7DBF4IKBKB | |
| SCHEMBL11149355 | 0.78 | LIMK1 (0.45) | LIMK1HPGDTP53GSK3B | |
| SCHEMBL11344205 | 0.76 | TP53 (0.41) | LIMK1CLK1IKBKBCHUKTP53 | |
| SCHEMBL11156297 | 0.74 | PRMT5 (0.36) | — | |
| SCHEMBL11342323 | 0.70 | THRB (0.37) | TP53ADORA2AGSK3B | |
| SCHEMBL11339514 | 0.70 | KDM4E (0.44) | HPGDTP53ADORA2A | |
| SCHEMBL11334717 | 0.70 | THRB (0.44) | HPGDTP53 | |
| SCHEMBL11342580 | 0.70 | THRB (0.39) | LIMK1IKBKBCHUKHPGDTP53 | |
| SCHEMBL30382671 | 0.70 | CLK1 (0.61) | LIMK1CLK1CDC7DBF4IKBKB | |
| SCHEMBL20120214 | 0.70 | CLK1 (0.61) | LIMK1CLK1CDC7DBF4IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |
| US-4220776-A | TREATMENT OF RHINOVIRAL INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0004319-A1 | N-(pyridothienopyrazol) amides, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-10-03 | — | — | EP | disclosed |