Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 3/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 3/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11331479 | 0.82 | LIMK1 (0.51) | LIMK1CLK1CDC7DBF4HPGD | |
| SCHEMBL11448777 | 0.79 | LIMK1 (0.45) | LIMK1CLK1CDC7DBF4HPGD | |
| SCHEMBL11339559 | 0.73 | HTT (0.47) | HPGDTHRBALDH1A1ADORA3 | |
| SCHEMBL11342500 | 0.71 | KMT2A (0.43) | HPGDALDH1A1 | |
| SCHEMBL11344145 | 0.71 | TDP1 (0.36) | LIMK1CLK1HPGDIKBKBCHUK | |
| SCHEMBL20120214 | 0.66 | CLK1 (0.61) | LIMK1CLK1CDC7DBF4HPGD | |
| SCHEMBL30382671 | 0.66 | CLK1 (0.61) | LIMK1CLK1CDC7DBF4HPGD | |
| SCHEMBL17489955 | 0.64 | LIMK1 (0.54) | LIMK1CLK1CDC7DBF4HPGD | |
| SCHEMBL30187948 | 0.64 | CLK1 (1.00) | LIMK1CLK1CDC7DBF4HPGD | |
| SCHEMBL12807147 | 0.64 | CLK1 (1.00) | LIMK1CLK1CDC7DBF4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |
| US-4220776-A | TREATMENT OF RHINOVIRAL INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0004319-A1 | N-(pyridothienopyrazol) amides, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-10-03 | — | — | EP | disclosed |