Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11344205 | 0.84 | TP53 (0.41) | THRBLMNATP53KDM4EALDH1A1 | |
| SCHEMBL11153276 | 0.83 | MAPT (0.40) | LMNATP53KDM4EALDH1A1HPGD | |
| SCHEMBL11342580 | 0.83 | THRB (0.39) | THRBLMNATP53KDM4EHPGD | |
| SCHEMBL11339514 | 0.83 | KDM4E (0.44) | THRBLMNATP53KDM4EALDH1A1 | |
| SCHEMBL11345577 | 0.82 | THRB (0.39) | THRBLMNATP53KDM4EHPGD | |
| SCHEMBL11347177 | 0.82 | THRB (0.39) | THRBLMNATP53KDM4EHPGD | |
| SCHEMBL11342323 | 0.80 | THRB (0.37) | THRBTP53KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11333160 | 0.77 | STK17B (0.41) | ALDH1A1KAT2BADORA1 | |
| SCHEMBL11146650 | 0.75 | MAPT (0.35) | THRBLMNATP53KDM4EALDH1A1 | |
| SCHEMBL14296844 | 0.73 | AURKB (0.45) | ALDH1A1KMT2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |