Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11456844 | 0.97 | SLC18A3 (0.48) | SLC18A3SIGMAR1OPRM1OPRK1MLYCD | |
| SCHEMBL11331001 | 0.90 | SLC18A3 (0.48) | SLC18A3SIGMAR1MLYCDL3MBTL1MEN1 | |
| SCHEMBL11330691 | 0.87 | SIGMAR1 (0.38) | SLC18A3SIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL11569473 | 0.86 | SLC18A3 (0.46) | SLC18A3SIGMAR1MLYCDMEN1KMT2A | |
| SCHEMBL11346481 | 0.84 | SIGMAR1 (0.36) | SLC18A3SIGMAR1L3MBTL1MEN1KMT2A | |
| SCHEMBL11465734 | 0.84 | SIGMAR1 (0.37) | SIGMAR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11332124 | 0.84 | SLC18A3 (0.47) | SLC18A3SIGMAR1OPRM1OPRK1OPRD1 | |
| SCHEMBL11332175 | 0.83 | SIGMAR1 (0.42) | SIGMAR1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL11334204 | 0.81 | SLC18A3 (0.52) | SLC18A3SIGMAR1OPRM1OPRK1MLYCD | |
| SCHEMBL11338205 | 0.81 | MITF (0.53) | SIGMAR1OPRM1OPRK1MLYCDOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |