Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133185 | 1.00 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCA12 | |
| Hydrochloric Acid SCHEMBL1133180 | 0.99 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DCA12 | |
| SCHEMBL1132675 | 0.88 | REN (0.46) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL3389298 | 0.88 | REN (0.40) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL4955591 | 0.88 | REN (0.40) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL4955261 | 0.88 | REN (0.40) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL2175523 | 0.88 | REN (0.42) | PDE4BRENTP53SMN1; SMN2 | |
| SCHEMBL1133256 | 0.88 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL2178941 | 0.88 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DREN | |
| SCHEMBL1133253 | 0.88 | PDE4B (0.45) | PDE4APDE4BPDE4CPDE4DREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973175-B2 | pyrrolidine chemical intermediates useful in the synthesis of drugs, especially enzyme inhibitors, such as Aliskiren | NOVARTIS AG (CH) | 2011-07-05 | — | — | US | claimed |
| EP-2287153-A1 | Synthesis Of Renin Inhibitors Involving A Cycloaddition Reaction | Novartis AG (CH) | 2011-02-23 | — | — | EP | claimed |
| EP-1931629-B1 | SYNTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION | NOVARTIS AG (CH) | 2010-12-22 | — | — | EP | claimed |
| US-20080255369-A1 | Synthesis of Renin Inhibitors Involving a Cycloaddition Reaction | NOVARTIS AG (CH) | 2008-10-16 | — | — | US | claimed |
| EP-1931629-A1 | SYTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION | Novartis AG (CH) | 2008-06-18 | — | — | EP | claimed |
| WO-2007039183-A1 | SYTHESIS OF RENIN INHIBITORS INVOLVING A CYCLOADDITION REACTION | NOVARTIS AG (CH) | 2007-04-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255369-A1 | Synthesis of Renin Inhibitors Involving a Cycloaddition Reaction | REN, AGTR1, AGTR2 | PDE4A 1503/4885PDE4B 1472/4885PDE4C 2387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.