Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11335360 | 0.74 | TSHR (0.43) | HTR6TSHRMAPK1HTTCHRM2 | |
| SCHEMBL11332587 | 0.74 | NPC1 (0.46) | TSHRMAPK1HTTKMT2AMAOA | |
| SCHEMBL11341470 | 0.73 | ALDH1A1 (0.42) | HTR6TSHRMAPK1HTTKMT2A | |
| SCHEMBL11329332 | 0.73 | CHRM2 (0.39) | HTR6TSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL26244749 | 0.72 | CHRM2 (0.38) | HTR6TSHRCHRM2CHRM4CHRM5 | |
| SCHEMBL11341220 | 0.69 | HTR6 (0.42) | HTR6MAOAMAOB | |
| SCHEMBL11334978 | 0.69 | CYP1A2 (0.65) | HTR6TSHRKMT2AMAOAMEN1 | |
| SCHEMBL11332106 | 0.69 | TSHR (0.41) | HTR6TSHRMAPK1HTTKMT2A | |
| SCHEMBL11336117 | 0.69 | QDPR (0.46) | HTR6TSHRMAPK1HTT | |
| SCHEMBL11328663 | 0.68 | TSHR (0.40) | HTR6TSHRMAPK1HTTMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4259338-A | Benzofuranyl-tetrahydropyridines and -piperidines, their acid addition salts and antidepressant preparations thereof | CIBA-GEIGY CORPORATION (US) | 1981-03-31 | — | — | US | disclosed |
| EP-0006524-A1 | Tetrahydropyridine and tetrahydropiperidine derivatives, their acid addition salts, processes for their preparation and pharmaceutical compositions containing them | CIBA-GEIGY AG (CH) | 1980-01-09 | — | — | EP | disclosed |