SCHEMBL11332811

SCHEMBL11332811

CCN(CC)C(=O)c1ccc(CCc2ccccc2N)nc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 6/20 0.43
ALDH1A1 P00352 5/20 0.43
MAPT P10636 1/20 0.43
HCRTR1 O43613 4/20 0.43
HCRTR2 O43614 4/20 0.43
LMNA P02545 1/20 0.42
GRM5 P41594 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.40
HSP90AA1 P07900 1/20 0.39
HSP90AB1 P08238 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.37
CYP2D6 P10635 1/20 0.37
OPRD1 P41143 1/20 0.37
KCNH2 Q12809 1/20 0.37
MLYCD O95822 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL11329758 0.99 HPGD (0.43) HPGDALDH1A1MAPTHCRTR1HCRTR2
SCHEMBL11843331 0.82 ALDH1A1 (0.41) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL11843337 0.82 ALDH1A1 (0.41) ALDH1A1MAPTLMNAMEN1KMT2A
SCHEMBL11330296 0.81 HSD17B10 (0.46) HPGDALDH1A1MAPTHCRTR1HCRTR2
SCHEMBL11335080 0.80 HCRTR1 (0.41) HPGDALDH1A1MAPTHCRTR1HCRTR2
SCHEMBL12844304 0.76 GRM5 (0.52) HPGDALDH1A1MAPTLMNAGRM5
SCHEMBL29133579 0.75 GRM5 (0.51) HPGDALDH1A1MAPTLMNAGRM5
SCHEMBL5434700 0.75 RARB (0.47) HPGDALDH1A1MAPTLMNAGRM5
SCHEMBL5312194 0.73 SMN1; SMN2 (0.55) HPGDALDH1A1MAPTLMNAGRM5
SCHEMBL11324240 0.73 HRH3 (0.47) MAPTLMNAL3MBTL1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE30812-E ANTIARRHTHMIA AGENTS MEAD JOHNSON & COMPANY (US) 1981-12-01 US disclosed
US-RE30811-E SEROTONIN ANTAGONISTS, ANTIARRHYTHMIA AGENTS MEAD JOHNSON & COMPANY (US) 1981-12-01 US disclosed
US-4064254-A ANTIARRHYTHMIC AND ANTISEROTONINE AGENTS MEAD JOHNSON & COMPANY (US) 1977-12-20 US disclosed
US-4000143-A ANTIARRHYTHMIC AND ANTISEROTONIN AGENTS MEAD JOHNSON & COMPANY (US) 1976-12-28 US disclosed
US-3931195-A ANTIARRHYTHMIA, ANTISEROTONIN MEAD JOHNSON & COMPANY (US) 1976-01-06 US disclosed