Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.88 |
| ▸ | DRD3 | P35462 | 9/20 | 0.88 |
| ▸ | DRD4 | P21917 | 8/20 | 0.88 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | HTR7 | P34969 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10570451 | 0.93 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL252295 | 0.91 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL10574132 | 0.90 | DRD2 (0.95) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL14974690 | 0.90 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL23097782 | 0.88 | DRD2 (0.82) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL251472 | 0.87 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097785 | 0.87 | DRD2 (0.82) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL23097745 | 0.86 | DRD2 (0.82) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL10835764 | 0.85 | DRD2 (0.68) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL10573201 | 0.85 | DRD2 (0.95) | DRD2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005828-B1 | NEW SUBSTITUTED PHENYLPIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-03-11 | — | — | EP | disclosed |
| US-4234584-A | NEUROLEPTIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-18 | — | — | US | disclosed |
| EP-0005828-A1 | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-12-12 | — | — | EP | disclosed |