Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 8-Hydroxy Quinaldine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.57 |
| ▸ | CCR1 | P32246 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 8-Hydroxy Quinaldine SCHEMBL28411870 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL31268359 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL1714541 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL1715251 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL2059590 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL546578 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL546344 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL4399934 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL1714719 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 | |
| 8-Hydroxy Quinaldine SCHEMBL28411833 | 0.96 | METAP2 (0.57) | METAP2CCR1RAB9ACCR5PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9252383-B2 | Cathode coating | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20100289009-A1 | CATHODE COATING | MERCK PATENT GMBH (DE) | 2010-11-18 | — | — | US | claimed |
| EP-2044638-A2 | CATHODE COATING | Merck Patent GmbH (DE) | 2009-04-08 | — | — | EP | claimed |
| WO-2008012581-A2 | CATHODE COATING | MERCK PATENT GMBH (DE) | 2008-01-31 | — | — | WO | claimed |
| US-20240237526-A1 | ORGANIC COMPOUND, LIGHT-EMITTING DEVICE, LIGHT-EMITTING APPARATUS, AND ELECTRONIC DEVICE | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2024-07-11 | — | — | US | disclosed |
| US-20240164134-A1 | Light-Emitting Device, Metal Complex, Light-Emitting Apparatus, Electronic Apparatus, And Lighting Device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2024-05-16 | — | — | US | disclosed |
| US-11889712-B2 | Light-emitting device including organic compound and metal complex | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. | 2024-01-30 | — | — | US | disclosed |
| WO-2023187545-A1 | METHOD FOR FABRICATING LIGHT-EMITTING DEVICE | 株式会社半導体エネルギー研究所 | 2023-10-05 | — | — | WO | disclosed |
| WO-2023131854-A1 | DISPLAY DEVICE | 株式会社半導体エネルギー研究所 | 2023-07-13 | — | — | WO | disclosed |
| US-20210336176-A1 | Light-Emitting Device, Metal Complex, Light-Emitting Apparatus, Electronic Apparatus, and Lighting Device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2021-10-28 | — | — | US | disclosed |
| CN-111279507-A | Organic electroluminescent element | 住友化学株式会社 | 2020-06-12 | — | — | CN | disclosed |
| CN-107665958-B | Printing type OLED device and manufacturing method thereof | 广东聚华印刷显示技术有限公司 | 2020-01-24 | — | — | CN | disclosed |
| US-9252383-B2 | Cathode coating | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | disclosed |
| EP-2286474-A2 | METHOD OF MAKING AN OLED | Merck Patent GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |
| US-20100289009-A1 | CATHODE COATING | MERCK PATENT GMBH (DE) | 2010-11-18 | — | — | US | disclosed |
| WO-2009149860-A2 | METHOD OF MAKING AN OLED | MERCK PATENT GMBH (DE) | 2009-12-17 | — | — | WO | disclosed |
| EP-2044638-A2 | CATHODE COATING | Merck Patent GmbH (DE) | 2009-04-08 | — | — | EP | disclosed |
| WO-2008012581-A2 | CATHODE COATING | MERCK PATENT GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240237526-A1 | ORGANIC COMPOUND, LIGHT-EMITTING DEVICE, LIGHT-EMITTING APPARATUS, AND ELECTRONIC DEVICE | CHRM1, CYP1A1, HAX1 | METAP2 3952/4885CCR1 169/4885RAB9A 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.