Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 6/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11144647 | 0.84 | RAB9A (0.43) | STK17BADORA3ADORA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11344205 | 0.82 | TP53 (0.41) | ADORA3KAT2BALDH1A1SMN1; SMN2 | |
| SCHEMBL11342580 | 0.77 | THRB (0.39) | KAT2BSMN1; SMN2RAB9A | |
| SCHEMBL11342323 | 0.77 | THRB (0.37) | ADORA3ADORA1ALDH1A1L3MBTL1 | |
| SCHEMBL11339514 | 0.77 | KDM4E (0.44) | KAT2BALDH1A1HTTSMN1; SMN2RAB9A | |
| SCHEMBL11334717 | 0.77 | THRB (0.44) | ADORA1KAT2BALDH1A1 | |
| SCHEMBL11347177 | 0.76 | THRB (0.39) | SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL11345577 | 0.76 | THRB (0.39) | KAT2BSMN1; SMN2RAB9A | |
| SCHEMBL14794611 | 0.74 | ALDH1A1 (0.57) | ALDH1A1HTTSMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL14296844 | 0.71 | AURKB (0.45) | ADORA3ADORA1ALDH1A1SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |
| US-4220776-A | TREATMENT OF RHINOVIRAL INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0004319-A1 | N-(pyridothienopyrazol) amides, process for their preparation and pharmaceutical compositions containing them | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1979-10-03 | — | — | EP | disclosed |