Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | ACACA | Q13085 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11345577 | 0.92 | THRB (0.39) | THRBTP53NPC1RAB9AACACB | |
| SCHEMBL11342580 | 0.90 | THRB (0.39) | THRBTP53NPC1RAB9AACACB | |
| SCHEMBL11344205 | 0.83 | TP53 (0.41) | THRBTP53MAPTLMNAPOLB | |
| SCHEMBL11334717 | 0.82 | THRB (0.44) | THRBTP53LMNAKDM4EHPGD | |
| SCHEMBL11344145 | 0.81 | TDP1 (0.36) | THRBTP53NPC1RAB9AL3MBTL1 | |
| SCHEMBL11339514 | 0.80 | KDM4E (0.44) | THRBTP53NPC1RAB9AL3MBTL1 | |
| SCHEMBL11342323 | 0.80 | THRB (0.37) | THRBTP53L3MBTL1MAPTPOLB | |
| SCHEMBL11333160 | 0.76 | STK17B (0.41) | RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL11147960 | 0.73 | ALDH1A1 (0.38) | TP53NPC1RAB9AMAPTLMNA | |
| SCHEMBL14296844 | 0.72 | AURKB (0.45) | NPC1RAB9AMAPTSMN1; SMN2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004319-B1 | N-(PYRIDOTHIENOPYRAZOL) AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-05 | — | — | EP | disclosed |
| US-4220776-A | TREATMENT OF RHINOVIRAL INFECTIONS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1980-09-02 | — | — | US | disclosed |