SCHEMBL11337115

SCHEMBL11337115

CNC(=O)Sc1ccc(Cl)c(Cl)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TERT O14746 1/20 0.42
EPHX1 P07099 2/20 0.40
EPHX2 P34913 2/20 0.40
KDM4E B2RXH2 4/20 0.40
LMNA P02545 3/20 0.40
KMT2A Q03164 3/20 0.40
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
RAB9A P51151 2/20 0.40
CYP3A4 P08684 1/20 0.39
APEX1 P27695 1/20 0.39
TSHR P16473 2/20 0.38
USP7 Q93009 1/20 0.38
CA2 P00918 1/20 0.37
CA4 P22748 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
HAO1 Q9UJM8 1/20 0.37
HTT P42858 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11337380 0.81 CYP3A4 (0.42) TERTEPHX1EPHX2LMNAKMT2A
SCHEMBL11334310 0.81 SMN1; SMN2 (0.42) TERTEPHX1EPHX2LMNAKMT2A
SCHEMBL11662147 0.79 MAPT (0.53) LMNAALDH1A1MAPTRAB9ATSHR
SCHEMBL11327273 0.78 KMT2A (0.54) TERTKDM4EKMT2AALDH1A1RAB9A
SCHEMBL11659238 0.77 TSHR (0.39) TERTEPHX1EPHX2KMT2AALDH1A1
SCHEMBL11336144 0.77 HPGD (0.57) KDM4ELMNAKMT2AALDH1A1RAB9A
SCHEMBL11576332 0.77 ALDH1A1 (0.36) KDM4ELMNAKMT2AALDH1A1MAPT
SCHEMBL11688320 0.76 TERT (0.46) TERTEPHX1EPHX2KDM4EKMT2A
SCHEMBL11659456 0.76 HPGD (0.59) TERTKDM4ELMNAKMT2AALDH1A1
SCHEMBL10660742 0.75 EPHX1 (0.42) TERTEPHX1EPHX2KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4282168-A FUNGICIDES PPG INDUSTRIES, INC. (US) 1981-08-04 US claimed
US-4055657-A S-ARYL-N-ALKYL-THIOLCARBAMATES PPG INDUSTRIES, INC. (US) 1977-10-25 US claimed
US-4282168-A FUNGICIDES PPG INDUSTRIES, INC. (US) 1981-08-04 US disclosed
US-4055657-A S-ARYL-N-ALKYL-THIOLCARBAMATES PPG INDUSTRIES, INC. (US) 1977-10-25 US disclosed