Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.35 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.35 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.35 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | PIM1 | P11309 | 4/20 | 0.34 |
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1658272 | 0.90 | GPR119 (0.45) | GPR119PIM1PDE4DDPP4 | |
| SCHEMBL1658386 | 0.87 | GUCY1B2 (0.36) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PIM1 | |
| SCHEMBL1133778 | 0.86 | MET (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PIM1 | |
| SCHEMBL1296781 | 0.76 | GPR119 (0.41) | GPR119METNQO2PDE4D | |
| SCHEMBL1133917 | 0.74 | MET (0.53) | PIM1METNQO2 | |
| SCHEMBL1133888 | 0.73 | CYP1A2 (0.43) | PIM1METNQO2 | |
| SCHEMBL1133887 | 0.72 | CYP1A2 (0.43) | PIM1METNQO2 | |
| SCHEMBL1133840 | 0.72 | PIM1 (0.43) | PIM1METNQO2 | |
| SCHEMBL2489896 | 0.69 | MET (0.61) | METNQO2 | |
| SCHEMBL1296715 | 0.68 | MET (0.76) | METNQO2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285811-B1 | 3-(3-PYRIMIDIN-2-YL-BENZYL)-[1,2,4]-TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2012-12-05 | — | — | EP | disclosed |
| EP-2285811-A1 | 3-(3-PYRIMIDIN-2-YL-BENZYL)-Ý1,2,4¨TRIAZOLOÝ4,3-B¨PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS | Merck Patent GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009152920-A1 | 3-(3-PYRIMIDIN-2-YL-BENZYL)-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES AS MET KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2009-12-23 | — | — | WO | disclosed |