SCHEMBL1134085

SCHEMBL1134085

COc1cccc(CNc2ccccc2)c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.76
MAPT P10636 5/20 0.62
MAOB P27338 1/20 0.61
KDM4E B2RXH2 3/20 0.61
ALDH1A1 P00352 3/20 0.61
MEN1 O00255 3/20 0.61
KMT2A Q03164 3/20 0.61
GAA P10253 2/20 0.61
ABCB1 P08183 1/20 0.60
ABCG2 Q9UNQ0 1/20 0.60
THRB P10828 1/20 0.57
PKM P14618 1/20 0.57
RAB9A P51151 1/20 0.57
BLM P54132 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
NOS1 P29475 1/20 0.57
APP P05067 1/20 0.56
CHRM2 P08172 1/20 0.55
HTT P42858 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30373777 1.00 HIF1A (0.76) HIF1AMAPTMAOBKDM4EALDH1A1
SCHEMBL24097464 0.91 MAPT (0.68) HIF1AMAPTKDM4EALDH1A1MEN1
SCHEMBL6695006 0.91 MAPT (0.68) HIF1AMAPTMAOBKDM4EALDH1A1
SCHEMBL1757487 0.90 HIF1A (0.63) HIF1AMAPTMAOBKDM4EALDH1A1
SCHEMBL30854961 0.85 HIF1A (0.59) HIF1AMAPTKDM4EALDH1A1MEN1
SCHEMBL25547419 0.85 HIF1A (0.63) HIF1AMAPTMAOBKDM4EALDH1A1
SCHEMBL2987758 0.85 HIF1A (0.63) HIF1AMAPTKDM4EALDH1A1MEN1
SCHEMBL5536027 0.85 HIF1A (0.59) HIF1AMAPTMAOBKDM4EALDH1A1
SCHEMBL21035304 0.84 MAPT (0.64) HIF1AMAPTKDM4EALDH1A1MEN1
SCHEMBL631899 0.84 MAPT (0.71) HIF1AMAPTKDM4EALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110305025-B Method for synthesizing benzylamine compound by imine catalytic hydrogenation 衢州学院 2022-05-06 CN disclosed
EP-2285339-B1 INITIATOR SYSTEM CONTAINING A DIARYLAKYLAMINE DERIVATIVE, HARDENABLE COMPOSITION AND USE THEREOF 3M INNOVATIVE PROPERTIES CO (US) 2012-12-19 EP disclosed
US-8314162-B2 Initiator system containing a diarylalkylamine derivate, hardenable composition and use thereof 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-11-20 US disclosed
CN-102112096-A Initiator system containing a diarylakylamine derivative, hardenable composition and use thereof 3M INNOVATIVE PROPERTIES CO 2011-06-29 CN disclosed
US-20110077361-A1 INITIATOR SYSTEM CONTAINING A DIARYLALKYLAMINE DERIVATE, HARDENABLE COMPOSITION AND USE THEREOF SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2011-03-31 US disclosed
EP-2285339-A1 INITIATOR SYSTEM CONTAINING A DIARYLAKYLAMINE DERIVATIVE, HARDENABLE COMPOSITION AND USE THEREOF 3M Innovative Properties Company (US) 2011-02-23 EP disclosed
WO-2009151957-A1 INITIATOR SYSTEM CONTAINING A DIARYLAKYLAMINE DERIVATIVE, HARDENABLE COMPOSITION AND USE THEREOF 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-12-17 WO disclosed
EP-2133064-A1 Initiator system containing a diarylalkylamine derivate, hardenable composition and use thereof 3M Innovative Properties Company (US) 2009-12-16 EP disclosed
EP-0598962-A1 Imidazole derivatives as calcium channel blockers NEUROSEARCH A/S (DK) 1994-06-01 EP disclosed
US-5296493-A Analgesics or antiischemics NEUROSEARCH A/S (DK) 1994-03-22 US disclosed