Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.31 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.30 |
| ▸ | KDM4A | O75164 | 2/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.30 |
| ▸ | TET3 | O43151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL10543525 | 0.93 | GPR84 (0.42) | LMNACAMK2APDE4AGPR84FFAR1 | |
| Succinic Acid SCHEMBL1625843 | 0.86 | CAMK2A (0.38) | LMNAALKBH5SUCNR1EGLN1CAMK2A | |
| SCHEMBL792924 | 0.85 | LMNA (0.36) | LMNA | |
| Ethylene Glycol SCHEMBL10971986 | 0.83 | LMNA (0.35) | LMNA | |
| Glycerin SCHEMBL5713070 | 0.79 | LMNA (0.41) | LMNA | |
| SCHEMBL7174857 | 0.77 | LMNA (0.44) | LMNAGPR84FFAR1FFAR4 | |
| SCHEMBL5428969 | 0.76 | GPR84 (0.34) | LMNACAMK2AGPR84FFAR1FFAR4 | |
| SCHEMBL11513135 | 0.74 | PDE4A (0.40) | PDE4A | |
| SCHEMBL9489121 | 0.74 | MEN1 (0.48) | LMNA | |
| SCHEMBL2564624 | 0.74 | MEN1 (0.48) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293657-A | Stable melamine polyol dispersions, a process for their manufacture and for the preparation of foamed polyurethane plastics | BASF AKTIENGESELLSCHAFT (DE) | 1981-10-06 | — | — | US | disclosed |