Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.31 |
| ▸ | KDM4A | O75164 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.31 |
| ▸ | TET3 | O43151 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.30 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686008 | 0.88 | PTPN1 (0.38) | PTPN1 | |
| Succinic Acid SCHEMBL11344005 | 0.86 | LMNA (0.35) | CAMK2AGPR84FFAR1FFAR4TET2 | |
| Azelaic Acid SCHEMBL11385292 | 0.84 | GPR84 (0.37) | GPR84FFAR1FFAR4 | |
| Adipic Acid SCHEMBL10543525 | 0.83 | GPR84 (0.42) | CAMK2AGPR84FFAR1FFAR4PTPN1 | |
| SCHEMBL6652106 | 0.80 | PTPN1 (0.39) | PTPN1LMNA | |
| SCHEMBL1962563 | 0.80 | ALDH1A1 (0.43) | GPR84FFAR1FFAR4LMNA | |
| SCHEMBL17331075 | 0.80 | CAMK2A (0.38) | CAMK2AGPR84FFAR1FFAR4PTPN1 | |
| SCHEMBL8577897 | 0.76 | THRB (0.36) | — | |
| SCHEMBL1771656 | 0.75 | FFAR1 (0.42) | CAMK2AGPR84FFAR1FFAR4PTPN1 | |
| SCHEMBL1962190 | 0.75 | FFAR4 (0.53) | GPR84FFAR1FFAR4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897901-B1 | BIODEGRADABLE POLYMER, PRODUCTION METHOD THEREOF, MOLDED PRODUCT THEREOF, AND USE THEREOF | MITSUI CHEMICALS INC (JP) | 2015-03-11 | — | — | EP | disclosed |
| US-7928180-B2 | Biodegradable polymer, production method thereof, molded product thereof, and use thereof | MITSUI CHEMICALS, INC. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-20090142982-A1 | Biodegradable Polymer, Production Method Thereof, Molded Product Thereof, and Use Thereof | MITSUI CHEMICALS INC. (JP) | 2009-06-04 | — | — | US | disclosed |
| EP-1897901-A1 | BIODEGRADABLE POLYMER, PRODUCTION METHOD THEREOF, MOLDED PRODUCT THEREOF, AND USE THEREOF | Mitsui Chemicals, Inc. (JP) | 2008-03-12 | — | — | EP | disclosed |