Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SIK1 | P57059 | 1/20 | 0.30 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.30 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060031 | 0.91 | SIK1 (0.33) | SIK1SIK2SIK3 | |
| SCHEMBL11350752 | 0.87 | ALDH1A1 (0.39) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11053551 | 0.87 | ESR1 (0.34) | — | |
| SCHEMBL11474313 | 0.87 | MEN1 (0.31) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11354153 | 0.86 | EGFR (0.36) | SIK1SIK2SIK3 | |
| SCHEMBL11053485 | 0.86 | ESR2 (0.41) | — | |
| SCHEMBL11058852 | 0.86 | ELANE (0.34) | — | |
| SCHEMBL11055393 | 0.83 | ESR1 (0.38) | — | |
| SCHEMBL11055980 | 0.83 | ELANE (0.31) | SIK1SIK2SIK3 | |
| SCHEMBL11056006 | 0.82 | KCNH2 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4298608-A | LOCAL ANESTHETICS | WILLIAM H. RORER, INC. (US) | 1981-11-03 | — | — | US | disclosed |
| US-4198408-A | 1,4-DISUBSTITUTED-1,2-DIHYDRO-1,3,5-TRIHZIN-2-ONES | WILLIAM H. RORER, INC. (US) | 1980-04-15 | — | — | US | disclosed |