Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.71 |
| ▸ | CASP6 | P55212 | 2/20 | 0.70 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.70 |
| ▸ | TIMP3 | P35625 | 3/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | FGF1 | P05230 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342001 | 0.94 | PRMT1 (0.82) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL10905524 | 0.93 | CASP6 (0.70) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL11354668 | 0.91 | TIMP3 (0.60) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL11433597 | 0.88 | CASP6 (0.86) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL11344557 | 0.87 | PRMT1 (0.67) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL10907433 | 0.86 | CASP6 (0.80) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL11211030 | 0.85 | PRMT1 (0.67) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL27648929 | 0.85 | CASP6 (0.81) | PRMT1CASP6CTDSP1TIMP3SIRT1 | |
| SCHEMBL11425915 | 0.84 | CASP6 (0.63) | PRMT1CASP6CTDSP1SIRT1CA1 | |
| SCHEMBL14413308 | 0.84 | CASP6 (0.98) | PRMT1CASP6CTDSP1TIMP3SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |