Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064845 | 0.98 | SMN1; SMN2 (0.54) | SMN1; SMN2LTA4HKCNH2CHRNB2CHRNA4 | |
| SCHEMBL22191644 | 0.89 | FFAR1 (0.47) | SMN1; SMN2KCNH2GABRG2GABRB3GABRA5 | |
| SCHEMBL22191444 | 0.85 | GAA (0.47) | SMN1; SMN2HTTKDRALDH1A1KMT2A | |
| SCHEMBL22191758 | 0.84 | LTA4H (0.61) | LTA4HHTTMEN1ALDH1A1KMT2A | |
| SCHEMBL5386751 | 0.82 | HTT (0.52) | SMN1; SMN2HTTPTPN1PTPN11ALDH1A1 | |
| SCHEMBL22191439 | 0.82 | KDM4E (0.46) | KCNH2ALDH1A1HPGDLMNA | |
| SCHEMBL4651084 | 0.82 | HTR7 (0.58) | SMN1; SMN2KCNH2KDRPOLB | |
| SCHEMBL4147020 | 0.82 | KDM4E (0.46) | SMN1; SMN2KDRMEN1ALDH1A1KMT2A | |
| SCHEMBL1713545 | 0.81 | INSR (0.48) | SMN1; SMN2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL6122773 | 0.81 | CCNT1 (0.49) | KCNH2MEN1ALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285810-A1 | SELECTIVE LIGANDS FOR THE NEURONAL NICOTINIC RECEPTORS AND USES THEREOF | Abbott Laboratories (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009137308-A1 | SELECTIVE LIGANDS FOR THE NEURONAL NICOTINIC RECEPTORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2009-11-12 | — | — | WO | disclosed |