Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | METAP2 | P50579 | 1/20 | 0.56 |
| ▸ | METAP1 | P53582 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.54 |
| ▸ | GLRB | P48167 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359303 | 0.90 | RAB9A (0.58) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL45506 | 0.84 | MAPT (0.68) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL3268052 | 0.80 | RAB9A (0.66) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL2485504 | 0.80 | MAPT (0.66) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL3266547 | 0.79 | RAB9A (0.65) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL595019 | 0.79 | RAB9A (0.65) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL6031547 | 0.78 | KDM4E (0.79) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL29357142 | 0.78 | KDM4E (0.79) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL28989046 | 0.78 | RAB9A (0.59) | RAB9AMAPTLMNASMN1; SMN2NPC1 | |
| SCHEMBL595164 | 0.78 | MEN1 (0.65) | RAB9AMAPTLMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014079-B1 | SPIRO-QUINOLYLHYDANTOINS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1981-11-18 | — | — | EP | disclosed |
| EP-0014079-A1 | Spiro-quinolylhydantoins, process for their preparation and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4176185-A | ALDOSE REDUCTASE ENZYME INHIBITORS FOR TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1979-11-27 | — | — | US | disclosed |