SCHEMBL45506

SCHEMBL45506

O=C(O)COc1cccc2cccnc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.68
SMN1; SMN2 Q16637 4/20 0.68
RAB9A P51151 3/20 0.68
NPC1 O15118 3/20 0.68
L3MBTL1 Q9Y468 3/20 0.68
HDAC6 Q9UBN7 2/20 0.59
LMNA P02545 1/20 0.59
METAP2 P50579 1/20 0.59
METAP1 P53582 1/20 0.59
ALDH1A1 P00352 7/20 0.59
RXFP1 Q9HBX9 1/20 0.59
HPGD P15428 4/20 0.58
KDM4E B2RXH2 4/20 0.58
TDP1 Q9NUW8 1/20 0.58
TP53 P04637 2/20 0.58
POLB P06746 4/20 0.55
CASP1 P29466 2/20 0.55
USP2 O75604 2/20 0.55
GAA P10253 1/20 0.55
BRCA1 P38398 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9284192 0.87 MAPT (0.68) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL8871046 0.85 MAPT (0.67) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL4309362 0.85 MAPT (0.71) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL8871380 0.84 SMN1; SMN2 (0.65) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL11345751 0.84 RAB9A (0.63) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL9284194 0.83 MAPT (0.60) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL28678208 0.81 MAPT (1.00) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL8886917 0.81 MAPT (0.61) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL8628518 0.81 SMN1; SMN2 (1.00) MAPTSMN1; SMN2RAB9ANPC1L3MBTL1
SCHEMBL8359303 0.80 RAB9A (0.58) MAPTSMN1; SMN2RAB9ANPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1827 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120078025-A Application of compound in plant rooting and plant rooting composition 郑州森永生物科技有限公司 2025-06-03 CN claimed
CN-113367128-A Composition containing R-type oxadiazolyl aryl formamide compound and safener and application thereof 江苏清原农冠杂草防治有限公司 2021-09-10 CN claimed
US-10334851-B2 Herbicidal isoxazolo[5,4-B]pyridines BASF SE (DE) 2019-07-02 US claimed
US-20170367340-A1 Herbicidal Isoxazolo[5,4-B]pyridines BASF SE (DE) 2017-12-28 US claimed
EP-1651039-B1 OIL SUSPENSION CONCENTRATE CONTAINING DIFLUFENICAN BAYER IP GMBH (DE) 2017-01-04 EP claimed
US-20160295866-A1 COMPOSITION OF 1,5-DIMETHYL-6-THIOXO-3-(2,2,7-TRIFLUORO-3-OXO-4-(PROP-2-YNYL)-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-YL)-1,3,5-TRIAZINANE-2,4-DIONE BASF SE (DE) 2016-10-13 US claimed
EP-3068225-A1 COMPOSITION OF 1,5-DIMETHYL-6-THIOXO-3-(2,2,7-TRIFLUORO-3-OXO-4-(PROP-2-YNYL)-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-YL)-1,3,5-TRIAZINANE-2,4-DIONE BASF SE (DE) 2016-09-21 EP claimed
US-20160037777-A1 Herbicidal Isoxazolo[5,4-B]pyridines BASF SE (DE) 2016-02-11 US claimed
EP-2496573-B1 HERBICIDAL TETRAHYDROPHTHALIMIDES BASF SE (DE) 2015-07-01 EP claimed
WO-2015071087-A1 COMPOSITION OF 1,5-DIMETHYL-6-THIOXO-3-(2,2,7-TRIFLUORO-3-OXO-4-(PROP-2-YNYL)-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-YL)-1,3,5-TRIAZINANE-2,4-DIONE BASF SE (DE) 2015-05-21 WO claimed
US-20050026786-A1 Oil suspension concentrate BAYER CROPSCIENCE GMBH (DE) 2005-02-03 US claimed
US-20050026787-A1 Liquid formulation BAYER CROPSCIENCE GMBH (DE) 2005-02-03 US claimed
WO-2004071416-A2 NOVEL INHIBITORS OF FORMATION OF ADVANCED GLYCATION ENDPRODUCTS (AGES) CITY OF HOPE (US) 2004-08-26 WO claimed
US-20030220362-A1 Novel inhibitors of formation of advanced glycation endproducts (AGEs) CITY OF HOPE 2003-11-27 US claimed
US-20030069138-A1 Synergistic herbicidal mixture of a). a heteroaryloxy- or aryloxy-phenoxypropionic acid, or salt or ester and b). one or more herbicides that are selective in rice BAYER INTELLECTUAL PROPERTY GMBH (DE) 2003-04-10 US claimed
US-20020123428-A1 Can be used against harmful plants in crops, preferably in rice AVENTIS CROPSCIENCE GMBH (DE) 2002-09-05 US claimed
EP-0407341-B1 Selective herbicidal agent CIBA GEIGY AG (CH) 1995-12-06 EP claimed
EP-0626958-A1 SULFONYLUREAS AS HERBICIDES CIBA-GEIGY AG (CH) 1994-12-07 EP claimed
WO-1993017016-A1 SULFONYLUREAS AS HERBICIDES CIBA-GEIGY AG (CH) 1993-09-02 WO claimed
US-4335243-A ANALGESICS, NARCOTIC ANTAGONISTS STERLING DRUG INC. (US) 1982-06-15 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050026786-A1 Oil suspension concentrate LIPA, BLVRB, DDT MAPT 2040/4885SMN1; SMN2 3078/4885RAB9A 4759/4885
US-10334851-B2 Herbicidal isoxazolo[5,4-B]pyridines CYP4X1, PNPO, PRDX4 MAPT 3688/4885SMN1; SMN2 4074/4885RAB9A 2712/4885
US-20050026787-A1 Liquid formulation SOD1, GLO1, MDM2 MAPT 16/4885SMN1; SMN2 12/4885RAB9A 2984/4885
US-20160037777-A1 Herbicidal Isoxazolo[5,4-B]pyridines CYP4X1, PNPO, PRDX4 MAPT 3688/4885SMN1; SMN2 4074/4885RAB9A 2712/4885
US-20160295866-A1 COMPOSITION OF 1,5-DIMETHYL-6-THIOXO-3-(2,2,7-TRIFLUORO-3-OXO-4-(PROP-2-YNYL)-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-YL)-1,3,5-TRIAZINANE-2,4-DIONE TXN2, COX5A, PRDX5 MAPT 3046/4885SMN1; SMN2 3652/4885RAB9A 4509/4885
US-20170367340-A1 Herbicidal Isoxazolo[5,4-B]pyridines CYP4X1, PNPO, PRDX4 MAPT 3688/4885SMN1; SMN2 4074/4885RAB9A 2712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.