SCHEMBL29357142

SCHEMBL29357142

c1cnc2c(OCCOCCOCCOCCOc3cccc4cccnc34)cccc2c1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 6/20 0.79
MAPT P10636 6/20 0.79
CYP1A2 P05177 1/20 0.79
CYP3A4 P08684 1/20 0.79
CYP2C9 P11712 1/20 0.79
MAPK1 P28482 1/20 0.79
CYP2C19 P33261 1/20 0.79
RAB9A P51151 4/20 0.73
LMNA P02545 6/20 0.71
SMN1; SMN2 Q16637 3/20 0.71
ALDH1A1 P00352 4/20 0.69
HPGD P15428 1/20 0.68
HTT P42858 1/20 0.68
NPC1 O15118 3/20 0.64
NCF1 P14598 3/20 0.63
GAA P10253 2/20 0.62
MEN1 O00255 1/20 0.62
KMT2A Q03164 1/20 0.62
POLB P06746 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6031547 1.00 KDM4E (0.79) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL15533104 0.92 MAPT (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL27858514 0.92 KDM4E (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL18844291 0.92 MAPT (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL5170654 0.92 MAPT (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL18816619 0.92 MAPT (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL18816623 0.92 MAPT (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL4947880 0.92 KDM4E (0.69) KDM4EMAPTCYP1A2CYP3A4CYP2C9
Hydrochloric Acid SCHEMBL9438985 0.91 MAPT (0.68) KDM4EMAPTCYP1A2CYP3A4CYP2C9
SCHEMBL8059724 0.91 MAPT (0.68) KDM4EMAPTCYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12612391-B2 Cromolyn derivatives and uses thereof THE GENERAL HOSPITAL CORPORATION (US) 2026-04-28 US disclosed
US-12583881-B2 Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series OUT AND OUT CHEMISTRY S.P.R.L. (BE) 2026-03-24 US disclosed
US-20260014284-A1 PROCESS FOR PREPARATION OF RADIOLABELED STYRYLPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF JUBILANT DRAXIMAGE INC (CA) 2026-01-15 US disclosed
US-12383528-B2 Cromolyn esters and uses thereof THE GENERAL HOSPITAL CORPORATION (US) 2025-08-12 US disclosed
WO-2025122011-A9 TRIGLYCERIDE ANALOGS ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) 2025-07-17 WO disclosed
WO-2025122011-A1 TRIGLYCERIDE ANALOGS ACADEMISCH ZIEKENHUIS LEIDEN (h.o.d.n. LUMC) (NL) 2025-06-12 WO disclosed
US-20250025581-A1 Medical Imaging of Glycogen Synthase Kinase-3 with a PET Probe MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2025-01-23 US disclosed
US-20240327361-A1 RADIOLABELED COMPOSITIONS AND METHODS OF USE THEREOF THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-10-03 US disclosed
EP-4433454-A2 MEDICAL IMAGING OF GLYCOGEN SYNTHASE KINASE-3 WITH A PET PROBE Mayo Foundation for Medical Education and Research (US) 2024-09-25 EP disclosed
US-12090157-B2 Non-invasive pet imaging of CDK4/6 activation in cancer NEW YORK UNIVERSITY 2024-09-17 US disclosed
WO-2023205291-A2 TARGETING MYOCARDIAL TISSUE FOR DELIVERY OF THERAPEUTIC AND IMAGING AGENTS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2023-10-26 WO disclosed
WO-2023163033-A1 NOVEL COMPOUND, α-SYNUCLEIN AGGREGATE BINDER, AND USE THEREOF 国立研究開発法人量子科学技術研究開発機構 2023-08-31 WO disclosed
WO-2023091697-A2 MEDICAL IMAGING OF GLYCOGEN SYNTHASE KINASE-3 WITH A PET PROBE MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2023-05-25 WO disclosed
CN-115109120-A CD 8-specific capture agents, compositions and methods of use and preparation 英蒂分子公司 2022-09-27 CN disclosed
WO-2022174193-A1 RADIOLABELED COMPOSITIONS AND METHODS OF USE THEREOF THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2022-08-18 WO disclosed
WO-2022146914-A1 CROMOLYN DERIVATIVES AND USES THEREOF THE GENERAL HOSPITAL CORPORATION (US) 2022-07-07 WO disclosed
CN-109476721-B CD 8-specific capture agents, compositions and methods of use and preparation 英蒂分子公司 2022-06-28 CN disclosed
EP-3198284-B1 PALETTE-BASED SYSTEMS FOR ANALYTE CHARACTERIZATION TRACE ABILITY INC (US) 2022-03-30 EP disclosed
US-20220073552-A1 REAGENT AND PROCESS FOR THE SITE-SPECIFIC DEOXYFLUORINATION OF PEPTIDES STUDIENGESELLSCHAFT KOHLE MBH (DE) 2022-03-10 US disclosed
US-20220062222-A1 CROMOLYN ESTERS AND USES THEREOF THE GENERAL HOSPITAL CORPORATION 2022-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12612391-B2 Cromolyn derivatives and uses thereof HTT, PRNP, PSEN1 KDM4E 4158/4885MAPT 20/4885CYP1A2 3981/4885
US-20220062222-A1 CROMOLYN ESTERS AND USES THEREOF PRNP, HTT, PSEN1 KDM4E 4274/4885MAPT 15/4885CYP1A2 3935/4885
US-12383528-B2 Cromolyn esters and uses thereof PRNP, HTT, PSEN1 KDM4E 4274/4885MAPT 15/4885CYP1A2 3935/4885
US-20250025581-A1 Medical Imaging of Glycogen Synthase Kinase-3 with a PET Probe GYS2, GYS1, PKN3 KDM4E 1926/4885MAPT 2564/4885CYP1A2 2072/4885
US-20260014284-A1 PROCESS FOR PREPARATION OF RADIOLABELED STYRYLPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF NEFM, APP, PSEN2 KDM4E 2398/4885MAPT 13/4885CYP1A2 746/4885
US-20240327361-A1 RADIOLABELED COMPOSITIONS AND METHODS OF USE THEREOF HDAC1, HDAC3, HDAC5 KDM4E 114/4885MAPT 702/4885CYP1A2 2630/4885
US-12090157-B2 Non-invasive pet imaging of CDK4/6 activation in cancer CDK4, CDK6, CDKL4 KDM4E 746/4885MAPT 4079/4885CYP1A2 4104/4885
US-12583881-B2 Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series TMEM14C, FLT1, SLC6A12 KDM4E 2188/4885MAPT 3148/4885CYP1A2 1915/4885
US-20220073552-A1 REAGENT AND PROCESS FOR THE SITE-SPECIFIC DEOXYFLUORINATION OF PEPTIDES DNPEP, TYRO3, ABL1 KDM4E 2281/4885MAPT 3342/4885CYP1A2 2822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.