Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134602 | 1.00 | ABCG2 (0.54) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30271935 | 1.00 | ABCG2 (0.54) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30560976 | 0.85 | ABCG2 (0.71) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL285232 | 0.85 | ABCG2 (0.71) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL285231 | 0.85 | ABCG2 (0.71) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL4665597 | 0.84 | ABCG2 (0.69) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL28957727 | 0.83 | ABCG2 (0.55) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31501086 | 0.83 | ABCG2 (0.55) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21317646 | 0.83 | ABCG2 (0.55) | ABCG2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12672390 | 0.81 | ABCG2 (0.54) | ABCG2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240425452-A1 | ISOLATED TRANS ISOMER OF 3-(2-BROMO-3,4-DIHYDROXY-PHENYL)-N-(3,4,5-TRIHYDROXY-BENZYL)-THIOACRYLAMIDE | TYRNOVO LTD. (IL) | 2024-12-26 | — | — | US | disclosed |
| WO-2023079545-A1 | ISOLATED TRANS ISOMER OF 3-(2-BROMO-3,4-DIHYDROXY-PHENYL)-N-(3,4,5-TRIHYDROXY-BENZYL)-THIOACRYLAMIDE | TYRNOVO LTD. (IL) | 2023-05-11 | — | — | WO | disclosed |
| CN-115466205-A | Isolated trans isomer of 3- (2-bromo-3, 4-dihydroxy-phenyl) -N- (3, 4, 5-trihydroxy-benzyl) -thioacrylamide | 特尔诺沃有限公司 | 2022-12-13 | — | — | CN | disclosed |
| EP-2285774-B1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | YISSUM RES DEV CO (IL) | 2015-02-25 | — | — | EP | disclosed |
| US-8637575-B2 | Modulators of protein kinase signaling | NOVOTYR THERAPEUTICS LTD. (IL) | 2014-01-28 | — | — | US | disclosed |
| US-8536227-B2 | — | — | 2013-09-17 | — | — | US | disclosed |
| US-20110105618-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | NOVOTYR THERAPEUTICS LTD. (IL) | 2011-05-05 | — | — | US | disclosed |
| EP-2285774-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | Novotyr Therapeutics Ltd. (IL) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009147682-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | NOVOTYR THERAPEUTICS LTD. (IL) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105618-A1 | NOVEL MODULATORS OF PROTEIN KINASE SIGNALING | MAP3K20, MAP3K1, MAP3K6 | ABCG2 1622/4885KDM4E 1619/4885ALDH1A1 4678/4885 |
| US-20240425452-A1 | ISOLATED TRANS ISOMER OF 3-(2-BROMO-3,4-DIHYDROXY-PHENYL)-N-(3,4,5-TRIHYDROXY-BENZYL)-THIOACRYLAMIDE | TOP2B, TERT, TAC3 | ABCG2 203/4885KDM4E 2083/4885ALDH1A1 470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.