Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.33 |
| ▸ | CCR9 | P51686 | 4/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11359826 | 0.84 | PARP10 (0.47) | TDP1KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL11409814 | 0.83 | CYP2C19 (0.33) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL11478388 | 0.83 | PARP10 (0.39) | TDP1CA12CA1CA9KDM4E | |
| SCHEMBL11347014 | 0.81 | SMN1; SMN2 (0.39) | CA1KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL11351095 | 0.81 | TP53 (0.48) | TDP1KDM4ERAB9AKMT2ATP53 | |
| SCHEMBL11489038 | 0.81 | PARP15 (0.41) | NOTUMKDM4ENPC1RAB9AKMT2A | |
| SCHEMBL11346661 | 0.79 | PDE11A (0.53) | TDP1KDM4ENPC1RAB9AKMT2A | |
| SCHEMBL11350749 | 0.79 | SMN1; SMN2 (0.33) | JAK2JAK1TYK2JAK3KDM4E | |
| SCHEMBL11475697 | 0.79 | ALDH1A1 (0.39) | KDM4EKMT2AALOX5AP | |
| SCHEMBL11356753 | 0.78 | PDE1B (0.44) | TDP1CA12CA1CA9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005154-B1 | 1-OXO-1H-PYRIMIDO (6,1-B) BENZOTHIAZOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 1981-11-25 | — | — | EP | disclosed |
| US-4232024-A | ANTIALLERGENS | BOEHRINGER MANNHEIM GMBH (DE) | 1980-11-04 | — | — | US | disclosed |