Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GSTO1 | P78417 | 4/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11353531 | 1.00 | MEN1 (0.46) | MEN1KMT2ATSHRTDP1TP53 | |
| SCHEMBL11348810 | 0.91 | GSTO1 (0.44) | MEN1KMT2ATSHRTDP1CYP1A2 | |
| SCHEMBL11345142 | 0.89 | FABP4 (0.49) | MEN1KMT2ATSHRTDP1TP53 | |
| SCHEMBL5506453 | 0.89 | FABP4 (0.49) | MEN1KMT2ATSHRTDP1TP53 | |
| SCHEMBL11343142 | 0.82 | GSTO1 (0.53) | MEN1KMT2ATSHRTDP1CYP1A2 | |
| SCHEMBL11595388 | 0.81 | GSTO1 (0.50) | MEN1KMT2ATSHRTDP1TP53 | |
| SCHEMBL11348042 | 0.81 | ATM (0.51) | MEN1KMT2ATSHRTDP1CYP3A4 | |
| SCHEMBL11569347 | 0.80 | CA12 (0.46) | MEN1KMT2ATSHRTDP1TP53 | |
| SCHEMBL11342625 | 0.80 | MAPT (0.42) | MEN1KMT2ATDP1PDK1PDK2 | |
| SCHEMBL11527984 | 0.79 | GAA (0.47) | MEN1KMT2ATSHRTDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0001051-B1 | DERIVATIVES OF BENZENESULFONAMIDE, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-11 | — | — | EP | claimed |
| US-4235918-A | SALIDIURETICS, TREATMENT OF HYPERTONIC CONDITIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-25 | — | — | US | claimed |
| EP-0001051-B1 | DERIVATIVES OF BENZENESULFONAMIDE, METHOD FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-11 | — | — | EP | disclosed |
| EP-0001051-A2 | Derivatives of benzenesulfonamide, method for their preparation and pharmaceutical compositions containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-03-21 | — | — | EP | disclosed |