Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.72 |
| ▸ | MC4R | P32245 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | CCR3 | P51677 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | PHGDH | O43175 | 1/20 | 0.56 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037947 | 1.00 | SIGMAR1 (0.72) | SIGMAR1MC4RPKMCCR3LMNA | |
| SCHEMBL24023496 | 0.89 | CHKA (0.62) | SIGMAR1MC4RPKMCCR3LMNA | |
| SCHEMBL6583768 | 0.89 | CCR3 (0.69) | SIGMAR1MC4RCCR3LMNADRD4 | |
| SCHEMBL10868742 | 0.88 | MC4R (0.57) | SIGMAR1MC4RPKMCCR3LMNA | |
| SCHEMBL6659339 | 0.87 | SIGMAR1 (0.86) | SIGMAR1MC4RCCR3LMNADRD4 | |
| Hydrochloric Acid SCHEMBL1268041 | 0.87 | SIGMAR1 (0.59) | SIGMAR1MC4RPKMCCR3LMNA | |
| SCHEMBL2489199 | 0.85 | SIGMAR1 (1.00) | SIGMAR1MC4RCCR3LMNADRD4 | |
| SCHEMBL8188324 | 0.85 | SIGMAR1 (1.00) | SIGMAR1MC4RCCR3LMNADRD4 | |
| SCHEMBL1415730 | 0.85 | SIGMAR1 (1.00) | SIGMAR1MC4RCCR3LMNADRD4 | |
| SCHEMBL576868 | 0.85 | SIGMAR1 (1.00) | SIGMAR1MC4RCCR3LMNADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4243805-A | 3 Fluoro-10-piperazino-8-substituted 10,11-dihydrodibenzo-(bf) thiepins and method for the preparation thereof | SPOFA, SPOJENE PODNIKY PRO ZDRAVOTNICKOU VYROBU (CS) | 1981-01-06 | — | — | US | disclosed |