Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | MC4R | P32245 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037947 | 0.89 | SIGMAR1 (0.72) | PKMSIGMAR1ALDH1A1TSHRMC4R | |
| SCHEMBL11347486 | 0.89 | SIGMAR1 (0.72) | PKMSIGMAR1ALDH1A1TSHRMC4R | |
| SCHEMBL8070876 | 0.86 | LSS (0.63) | CHKAPKMSIGMAR1ALDH1A1HRH3 | |
| SCHEMBL16226080 | 0.85 | SIGMAR1 (0.78) | CHKASIGMAR1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL8070873 | 0.84 | PKM (0.56) | PKMSIGMAR1ALDH1A1LMNA | |
| SCHEMBL3687427 | 0.82 | CHKA (0.87) | CHKASIGMAR1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL3979002 | 0.80 | SIGMAR1 (0.63) | PKMSIGMAR1ALDH1A1LMNA | |
| SCHEMBL1690956 | 0.80 | CYP2D6 (0.85) | CHKASIGMAR1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL10868742 | 0.79 | MC4R (0.57) | PKMSIGMAR1ALDH1A1TSHRMC4R | |
| SCHEMBL16122104 | 0.79 | ALDH1A1 (0.65) | PKMALDH1A1TSHRHRH3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210353642-A1 | COMPOUNDS FOR TREATING MYELIN RELATED DISORDERS | CASE WESTERN RESERVE UNIVERSITY | 2021-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210353642-A1 | COMPOUNDS FOR TREATING MYELIN RELATED DISORDERS | PMP22, MAG, MYT1 | CHKA 536/4885PKM 3489/4885NCOA3 3932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.