Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 3/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15555724 | 0.89 | LMNA (0.50) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL1135057 | 0.84 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL582731 | 0.82 | PDE4B (0.47) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL583784 | 0.82 | ALDH1A1 (0.49) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL583465 | 0.80 | PDE4B (0.56) | PDE4BPDE1APDE1BPDE1C | |
| SCHEMBL5260430 | 0.76 | MAPT (0.47) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL1311733 | 0.74 | NPBWR1 (0.55) | PDE1APDE1BPDE1CNPBWR1MCHR1 | |
| SCHEMBL583574 | 0.72 | PDE5A (0.61) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL5262030 | 0.72 | ALDH1A1 (0.43) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL21796715 | 0.71 | NPBWR1 (0.51) | LMNAALOX15PDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027123-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2011-02-23 | — | — | EP | disclosed |
| EP-2027123-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2011-02-23 | — | — | EP | disclosed |
| US-7846923-B2 | Compounds and compositions as protein kinase inhbitors | IRM LLC (BM) | 2010-12-07 | — | — | US | disclosed |
| US-7846923-B2 | Compounds and compositions as protein kinase inhbitors | IRM LLC (BM) | 2010-12-07 | — | — | US | disclosed |
| US-20100048552-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| US-20100048552-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS | IRM LLC (BM) | 2010-02-25 | — | — | US | disclosed |
| EP-2027123-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134259-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-11-22 | — | — | WO | disclosed |
| WO-2007134259-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048552-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHBITORS | BMX, FYN, FRK | LMNA 4080/4885ALDH1A1 4202/4885MAPT 2536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.