Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11357489 | 0.87 | HDAC8 (0.56) | L3MBTL1ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL11161665 | 0.75 | NOTUM (0.54) | L3MBTL1ALDH1A1MAPTMAPK1NPC1 | |
| SCHEMBL11152712 | 0.74 | NOTUM (0.49) | L3MBTL1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL31494436 | 0.74 | RAB9A (0.46) | L3MBTL1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL120396 | 0.73 | NOTUM (0.68) | L3MBTL1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL91656 | 0.73 | SMN1; SMN2 (0.70) | L3MBTL1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL14081496 | 0.72 | NPC1 (1.00) | L3MBTL1ALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL12071899 | 0.72 | L3MBTL1 (0.57) | L3MBTL1ALDH1A1MAPTMAPK1NPC1 | |
| SCHEMBL10053916 | 0.72 | MAPT (0.57) | L3MBTL1ALDH1A1MAPTMAPK1NPC1 | |
| SCHEMBL11549559 | 0.72 | NPC1 (1.00) | L3MBTL1ALDH1A1MAPTMAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4294842-A | MALARIA | BURROUGHS WELLCOME CO. (US) | 1981-10-13 | — | — | US | disclosed |
| EP-0007529-A1 | Antiprotozoal oxadiazole derivatives, processes for their preparation and pharmaceutical formulations containing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-02-06 | — | — | EP | disclosed |