SCHEMBL1135166

SCHEMBL1135166

C=C(C(N)=O)C(C)(C)CN

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.39
KDM4E B2RXH2 1/20 0.34
CYP2D6 P10635 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28124390 0.80 TDP1 (0.39) TDP1
SCHEMBL1135248 0.80 KDM4E (0.39) KDM4ECYP2D6
SCHEMBL3229799 0.80 TDP1 (0.39) TDP1
Ammonia Solution, Strong SCHEMBL3915936 0.78 TDP1 (0.38) TDP1
SCHEMBL159079 0.78 TDP1 (0.38) TDP1
SCHEMBL10701254 0.78 LMNA (0.42) TDP1
SCHEMBL3432786 0.76 TDP1 (0.42) TDP1
SCHEMBL9126102 0.76 KDM4E (0.46) TDP1KDM4ECYP2D6
SCHEMBL17672216 0.75 TDP1 (0.35) TDP1
SCHEMBL1246191 0.73 TDP1 (0.33) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10166527-B2 Surface modification of porous base supports MERCK PATENT GMBH (DE) 2019-01-01 US claimed
EP-2310104-B1 MIXED GRAFT POLYMERS FOR ION EXCHANGE CHROMATOGRAPHY MERCK PATENT GMBH (DE) 2017-10-18 EP claimed
CN-106930142-A Drying strengthening agent composition and the method for improving paper dry strength 艺康美国股份有限公司 2017-07-07 CN claimed
US-20150298097-A1 SURFACE MODIFICATION OF POROUS BASE SUPPORTS MERCK PATENT GMBH (DE) 2015-10-22 US claimed
EP-2914377-A1 SURFACE MODIFICATION OF POROUS BASE SUPPORTS Merck Patent GmbH (DE) 2015-09-09 EP claimed
WO-2014067605-A1 SURFACE MODIFICATION OF POROUS BASE SUPPORTS MERCK PATENT GMBH (DE) 2014-05-08 WO claimed
US-8673988-B2 Graft copolymers for ion exchange chromatography MERCK PATENT GMBH (DE) 2014-03-18 US claimed
JP-2011529508-A 2011-12-08 JP claimed
US-20110136925-A1 GRAFT COPOLYMERS FOR ION EXCHANGE CHROMATOGRAPHY MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2011-06-09 US claimed
EP-2310104-A1 GRAFT COPOLYMERS FOR ION EXCHANGE CHROMATOGRAPHY Merck Patent GmbH (DE) 2011-04-20 EP claimed
EP-2153877-A1 Mixed graft polymers for ion exchange chromatography MERCK PATENT GmbH (DE) 2010-02-17 EP claimed
WO-2010012358-A1 GRAFT COPOLYMERS FOR ION EXCHANGE CHROMATOGRAPHY MERCK PATENT GMBH (DE) 2010-02-04 WO claimed
US-20220098233-A1 Mixed Bed Ion Exchange Adsorber EMD MILLIPORE CORP (US) 2022-03-31 US disclosed
US-11236125-B2 Mixed bed ion exchange adsorber EMD MILLIPORE CORPORATION (US) 2022-02-01 US disclosed
US-10166527-B2 Surface modification of porous base supports MERCK PATENT GMBH (DE) 2019-01-01 US disclosed
CN-107533290-A RESIST BASE MATERIAL, RESIST COMPOSITION, AND METHOD FOR FORMING RESIST PATTERN 三菱瓦斯化学株式会社 2018-01-02 CN disclosed
EP-2285485-A1 CE(IV)-INITIATED GRAFT POLYMERIZATION ON POLYMERS NOT CONTAINING HYDROXYL GROUPS Merck Patent GmbH (DE) 2011-02-23 EP disclosed
EP-2153877-A1 Mixed graft polymers for ion exchange chromatography MERCK PATENT GmbH (DE) 2010-02-17 EP disclosed
WO-2010012358-A1 GRAFT COPOLYMERS FOR ION EXCHANGE CHROMATOGRAPHY MERCK PATENT GMBH (DE) 2010-02-04 WO disclosed
WO-2009143953-A1 CE(IV)-INITIATED GRAFT POLYMERIZATION ON POLYMERS NOT CONTAINING HYDROXYL GROUPS MERCK PATENT GMBH (DE) 2009-12-03 WO disclosed